Delving into the Latest Updates on PAN-622-toxin conjugate(Sensei Biotherapeutics) with Synapse

Overview

Basic Info

Drug Type

Antibody drug conjugate (ADC)

Synonyms-

Target

HAAH

Mechanism

HAAH inhibitors(Aspartyl (asparaginyl) β-hydroxylase inhibitors)

Therapeutic Areas

Neoplasms

Active Indication-

Inactive Indication

Neoplasms

Originator Organization

Sensei Biotherapeutics, Inc.

Active Organization-

Inactive Organization

Sensei Biotherapeutics, Inc.

Drug Highest PhaseDiscontinuedDiscovery

First Approval Date-

Regulation-

Structure

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There is a need for novel effective and safe therapies for metastatic breast cancer based on targeting tumor-specific molecular markers of cancer. Human aspartyl (asparaginyl) β-hydroxylase (HAAH) is a highly conserved enzyme that hydroxylates epidermal growth factor-like domains in transformation-associated proteins and is overexpressed in a variety of cancers, including breast cancer. A fully human monoclonal antibody (mAb) PAN-622 has been developed to HAAH. In this study, they describe the development of PAN-622 mAb as an agent for imaging and radioimmunotherapy of metastatic breast cancer. PAN-622 was conjugated to several ligands such as DOTA, CHXA″, and DTPA to enable subsequent radiolabeling and its immunoreactivity was evaluated by an HAAH-specific enzyme-linked immunosorbent assay and binding to the HAAH-positive cells. As a result, DTPA-PAN-622 was chosen to investigate biodistribution in healthy CD-1 female mice and 4T1 mammary tumor-bearing BALB/c mice. The ¹¹¹In-DTPA-pan622 mAb concentrated in the primary tumors and to some degree in lung metastases as shown by SPECT/CT and Cherenkov imaging. A pilot therapy study with ²¹³Bi-DTPA-PAN-622 demonstrated a significant effect on the primary tumor. The authors concluded that human mAb PAN-622 to HAAH is a promising reagent for development of imaging and possible therapeutic agents for the treatment of metastatic breast cancer.

100 Deals associated with PAN-622-toxin conjugate(Sensei Biotherapeutics)

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