Delving into the Latest Updates on Ascorbyl gamolenate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ascorbyl-GLA, Ascorbyl-gamma-linolenic acid

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Target

AKR1B1

Mechanism

AKR1B1 inhibitors(Aldose reductase inhibitors)

Therapeutic Areas

Nervous System DiseasesEndocrinology and Metabolic Disease

Active Indication-

Inactive Indication

Diabetic Neuropathies

Originator Organization

Scotia

Active Organization-

Inactive Organization

Scotia Holdings PlcScotia

Drug Highest PhaseDiscontinuedPhase 1

First Approval Date-

Regulation-

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Structure

Molecular FormulaC24H36O7

InChIKeyFLRQOWAOMJMSTP-JJTRIOAGSA-N

CAS Registry109791-32-4

OBJECTIVEThe purpose of the present clinical study is to assess the effectiveness of a lipolytic solution containing sodium salt of ascorbic acid at 0.24% and a surfactant agent at 0.020% ascorbyl-palmitate (SAP) for the treatment of double chin.PATIENTS AND METHODSA total of 10 healthy adult subjects affected by double chin (8 female and 2 male) were evaluated in the present investigation. The patients were admitted to a total of 4 sessions, with biweekly procedures, without no other active agents addiction.RESULTSIn all the subjects a reduction of the convexity of the chin after the treatment with SAP was observed. Improvement in submental appearance was achieved in 90% (9/10) of the patients. One patient did not see any improvement in submental appearance after two section treatments and withdrew from the treatment.CONCLUSIONSIn conclusion, in the present study, a new adipocytolytic solution consisting of sodium ascorbate mixed with ascorbyl-palmitate was used with success as a surfactant agent for the treatment of double chin.

01 Feb 2022·Aesthetic Plastic Surgery

Invited Response on: A New Treatment for Local Adiposity With Ascorbic Acid and Ascorbyl-palmitate Solution: Clinical and Histological Study

Letter

Author: Ferraro, G ; Sbarbati, A ; Iorio, E L ; Scarano, A ; Amore, R ; Amuso, D

01 Feb 2022·Aesthetic Plastic Surgery

A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study

Letter

Author: Dong, Xinhang ; Jin, Xiaolei ; Zhang, Mingzi

100 Deals associated with Ascorbyl gamolenate

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