Kitasamycin Tartrate

A total of 155 Mycoplasma strains were examined for sensitivity to nine antibiotics and four nitrofurans by the agar dilution method. They consisted of 69 strains of Mycoplasma bovirhinis, 33 strains of M. bovigenitalium, 49 strains of Acholeplasma laidlawii and four strains of A. modicum isolated from the nasal secretions, tracheas and lungs of calves manifesting respiratory symptoms and from bovine genital tracts collected at a slaughterhouse. As a result, furamizole and mitomycin C showed the strongest growth-inhibiting effect on all the strains. They were followed in this effect by kitasamycin tartrate, spiramycin adipate, tylosin tartrate, tetracycline-HCl and chloramphenicol. Furthermore, these five drugs were followed in the effect by furazolidone, nitrofurantoin and sodium nifurstyrenate. Fradiomycin sulfate and kanamycin sulfate showed only little effect on all the strains. Erythromycin lactobionate showed a strong growth-inhibiting effect on the Acholeplasma strains, but not on the Mycoplasma strains. There were some cross resistant strains of the Acholeplasma species to the effects of the macrolides.

All Streptococcus pyogenes and Diplococcus pneumoniae strains tested in vitro were inhibited by 0.39 and 1.56 μg kitasamycin tartrate [37280-56-1]/ml, resp.; 98% of penicillin G sensitive and 99% of penicillin G resistant Staphylococcus aureus strains were inhibited by the higher concentrationMinocycline [10118-90-8], cephalothin [153-61-7], erythromycin [114-07-8], clindamycin [18323-44-9], and dicloxacillin [3116-76-5] were as active or more active than kitasamycin against gram-pos. cocci.