RARs agonists(Retinoic acid receptors agonists), RARα agonists(Retinoic acid receptor alpha agonists), RARβ2 agonists(Retinoic acid receptor beta agonists)

+ [1]

Therapeutic Areas

Skin and Musculoskeletal DiseasesOther Diseases

Active Indication-

Inactive Indication

Lentigo

Originator Organization

Almirall SA

Active Organization-

Inactive Organization

Almirall LLC

Drug Highest PhaseWithdrawn

First Approval Date

United States (10 Dec 1999),

Lentigo

Regulation-

Structure/Sequence

Molecular FormulaC27H36O4

InChIKeyVXWIYJTXZWNXJP-ABAXVIISSA-N

CAS Registry263878-34-8

100 Clinical Results associated with Mequinol/Tretinoin

100 Translational Medicine associated with Mequinol/Tretinoin

100 Patents (Medical) associated with Mequinol/Tretinoin

Literatures (Medical) associated with Mequinol/Tretinoin

01 Jul 2017·Journal of Chemical EcologyQ2 · ENVIRONMENTAL SCIENCE & ECOLOGY

Synthetic Co-Attractants of the Aggregation Pheromone of the Date Palm Root Borer Oryctes agamemnon

Q2 · ENVIRONMENTAL SCIENCE & ECOLOGY

Article

Author: Imed, Cheraief ; Couzi, Philippe ; Rochat, Didier ; Ouhichi, Monêem ; Chermiti, Brahim ; Frérot, Brigitte ; Pinier, Centina ; Saïd, Imen ; Hasni, Narjes

Laboratory and field investigations to identify and evaluate plant co-attractants of the aggregation pheromone of the date palm pest Oryctes agamemnon are reported. Volatiles emitted by freshly cut palm core and palm core with feeding males, were collected, analyzed by gas chromatography coupled to mass spectrometry and evaluated in olfactometers alone or combined with synthetic pheromone. A collection of palm odor without male effluvia was attractive alone and enhanced attraction to synthetic pheromone in an olfactometer similar to that to a collection of palm odor emitted with feeding males and containing natural pheromone. Behavioral responses to collections of palm volatiles were correlated to the amount of volatiles material in them. Enhancement of the attractiveness of the pheromone was not correlated to chemicals specific to beetle feeding. The chemicals common to the active collections extracts were benzoate esters, mostly ethyl benzoate, anisole derivatives and sesquiterpenes. Blends of the most abundant components of the extracts were evaluated for enhancement of the attractiveness of pheromone (1 μg) in olfactometers at 1 or 10 μg doses. The mixtures were further evaluated by field trapping in Tunisia at 3-10 mg/day using reference (6 mg/day) or experimental pheromone formulations. A mixture of ethyl benzoate, 4-methylanisole and farnesol (1:1:1 w/w at 6.5 mg/day) enhanced captures in pheromone baited traps in 2014 and 2015 and this mixture was as active as the natural palm bait. The practical prospect of the result for the management for O. agamemnon, and other palm beetles is discussed.

01 Sep 2008·Journal of drugs in dermatology : JDDQ4 · MEDICINE

Analytic quantification of the bleaching effect of a 4-hydroxyanisole-tretinoin combination on actinic lentigines.

Q4 · MEDICINE

Article

Author: Piérard-Franchimont, Claudine ; Vroome, Valérie ; Henry, Frédérique ; Quatresooz, Pascale ; Piérard, Gérald E

BACKGROUNDSolar lentigines represent a common feature of photoaging, particularly on the back of the hands. Bleaching agents are usually proposed to lighten the shade of the lesions.METHODSThe study was randomized and designed to assess the effect of a bleaching solution containing 2% mequinol (4-hydroxyanisole, 4HA) and 0.01% tretinoin (Solagé). The formulation was applied twice daily for 3 months on solar lentigines present on the back of one hand. The lesions on the other hand were treated with the ethyl alcohol vehicle which served as a control. Clinical diagnosis was confirmed using dermoscopy. In addition, objective measurements of the hypermelanosis were performed at 1-month intervals during and after treatment. Clinical assessments were used as well as narrow-band reflectance spectrophotometry, image analysis of video-recorded ultraviolet light-enhanced visualization (ULEV method) and photodensitometry of the corneomelametry test.RESULTSThe multipronged assessment of the lesional color demonstrated a significant lightening effect of the 4HA/tretinoin solution. This was demonstrated after 2 months of treatment and was maintained at least 2 months after stopping treatment.CONCLUSIONBoth the visual ratings and the objective bioinstrumental methods indicate the rapid lightening effect of the 4HA/tretinoin formulation. After stopping treatment, the rate of repigmentation appeared to have slowed compared to the depigmentation phase.

18 Nov 2006·Cancer LettersQ1 · MEDICINE

Biochemical basis of 4-hydroxyanisole induced cell toxicity towards B16-F0 melanoma cells

Q1 · MEDICINE

Article

Author: Moridani, Majid Y

In the current work we investigated for the first time the biochemical basis of 4-hydroxyanisole (4-HA) induced toxicity in B16-F0 melanoma cells. It was found that dicoumarol, a diaphorase inhibitor, and 1-bromoheptane, a GSH depleting agent, increased 4-HA induced toxicity towards B16-F0 cells whereas dithiothreitol, a thiol containing agent, and ascorbic acid (AA), a reducing agent, largely prevented 4-HA toxicity. TEMPOL and pyrogallol, free radical scavengers, did not significantly prevent 4-HA toxicity towards B16-F0 cells. GSH>AA>NADH prevented the o-quinone formation when 4-HA was metabolized by tyrosinase/O(2). 4-HA metabolism by horseradish peroxidase/H(2)O(2) was prevented more effectively by AA than NADH>GSH. We therefore concluded that quinone formation was the major pathway for 4-HA induced toxicity in B16-F0 melanoma cells whereas free radical formation played a negligible role in the 4-HA induced toxicity.

100 Deals associated with Mequinol/Tretinoin

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