Last update 08 May 2025

L1Au2

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Target
EGFR x TrxR
Action
antagonists, inhibitors
Mechanism
EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), TrxR inhibitors(Thioredoxin reductase inhibitors)
Therapeutic Areas
NeoplasmsRespiratory Diseases
Active Indication
Lung Cancer
Inactive Indication-
Originator Organization
Huazhong University of Science & TechnologyHuazhong University of Science & Technology
Active Organization
Huazhong University of Science & TechnologyHuazhong University of Science & Technology
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC24H24AuClFN6O2P
InChIKeyTVXSJXAKCZETHP-UHFFFAOYSA-N
CAS Registry3038386-42-1

Related

100 Clinical Results associated with L1Au2
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100 Translational Medicine associated with L1Au2
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100 Patents (Medical) associated with L1Au2
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1
Literatures (Medical) associated with L1Au2
13 Mar 2025Journal of Medicinal Chemistry
Dual-Targeting TrxR-EGFR Alkynyl-Au(I) Gefitinib Complex Induces Ferroptosis in Gefitinib-Resistant Lung Cancer via Degradation of GPX4
100 Deals associated with L1Au2
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lung CancerPreclinical
China
Huazhong University of Science & TechnologyHuazhong University of Science & Technology
19 Feb 2025
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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