In the examination of the stem of Blachia siamensis, 13 compounds were isolated, including 8 phenylpropanoids and 5 phenolic acids.To elucidate their chem. structures, techniques including NMR, spectral anal., and literature comparison were utilized.This study represents the first comprehensive investigation into the constituents of B. siamensis and also explores its the correlation between chem. classification and morphol. classification.

28 Mar 2025·Journal of Natural Products

Phenolics and Phenolic Glycosides from Wrightia pubescens and Their Hepatoprotective Activities

Article

Author: Huang, Xueshi ; Han, Li ; Yi, Ping ; Yang, Junwei ; Mu, Yu ; Chen, Xingxiang ; Zhang, Mimi ; Zhang, Zengguang ; Zhao, Zhilong ; Lv, Hang

Thirty compounds including 13 new phenolic glycosides (1-6, 9-15) and 17 known aromatic compounds and aromatic glycosides (7-8, 16-30) were isolated from the roots of Wrightia pubescens. The structures of the new phenolic glycosides were established by extensive NMR spectroscopic data analysis as well as chemical derivatization method. The isolated compounds were evaluated for their hepatoprotective activities using cell model of acetaminophen (APAP)-induced HepG2 cells. The results indicated that phenolic glycosides (2, 4, 5, 7, 8, 11, 13) pretreatment enhanced the cells viability and reduced the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT). The hepatoprotective mechanism of a representative new compound, wrightioside D (4), was further investigated. Compound 4 exhibited hepatoprotective effects via reducing oxidative stress by attenuating ROS formation and inhibiting apoptosis in APAP-treated HepG2 cells.

01 Mar 2025·Chemistry & Biodiversity

Identification of New Compounds from the Roots of Rubia tibetica Hook. f.

Article

Author: Zhang, Yu ; Xu, Chen‐Sen ; Liao, Zhi‐Xin ; Yu, Hao‐Lin ; Li, Qing ; Su, Yun‐Yun ; Wang, Jin ; Gu, Min‐Min

AbstractRubia tibetica Hook. f is a traditional Tibetan medicinal plant, with its roots serving as the primary medicinal part. Two new compounds, Rubiaxylm C and E (1 and 3), and one new natural compound, Rubiaxylm D (2) were isolated from R. tibetica, along with five known compounds (4–8). The structures of the previously undescribed compounds were elucidated by HR‐ESIMS, 1D/2D NMR spectroscopic data and electronic circular dichroism calculations. Compound 1 is a rare anthrone substituted with a carbonyl group at position 1. Furthermore, all isolated compounds were tested for their cytotoxicity against HepG2 cell lines.

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Indication	Highest Phase	Country/Location	Organization	Date
Ischemic stroke	Preclinical	China	China Pharmaceutical University	01 Jul 2021

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