Delving into the Latest Updates on Human immunoglobulin (Tonrol Biological) with Synapse

Overview

Basic Info

Drug Type

Immunoglobulin

Synonyms-

Target-

Mechanism

Immunomodulators

Therapeutic Areas

Immune System Diseases

Active Indication

Autoimmune DiseasesImmunoglobulin deficiency

Inactive Indication-

Originator Organization

Tonrol Biological Pharmaceutical Co. Ltd.

Active Organization

Tonrol Biological Pharmaceutical Co. Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (01 Jan 1998),

Autoimmune DiseasesImmunoglobulin deficiency

Regulation-

Login to view timeline

This study examined the effect of immunoglobulin A (IgA) and the IgA-binding lectin jacalin on the phagocytosis of type II group B streptococci (GBS). Strains possessing the trypsin-sensitive and trypsin-resistant components of the c protein (II/c) and type II GBS lacking the c protein (II) were examined by radiolabeled bacterial uptake, bactericidal assays, and electron microscopy. Type II/c GBS resisted phagocytosis by monocytes (4.9% +/- 0.8% uptake, mean +/- SE, n = 25) compared with type II GBS (8.5% +/- 1.4% uptake, n = 14, P = 0.03). Phagocytic killing by polymorphonuclear leukocytes was also less for the type II/c strain 78-471 than for the type II strain 79-176 (68% +/- 5% versus 86% +/- 4% reduction in CFU at 45 min, P = 0.03). IgA binding did not explain the resistance of type II/c GBS to phagocytosis. The uptake of type II/c GBS was not significantly different after opsonization in cord sera lacking endogenous IgA (5.93% +/- 1.4%) than in the same cord sera after addition of exogenous IgA (5.48% +/- 1.4%, P = 0.69, n = 9). Attempts to remove serum IgA with the IgA-binding lectin jacalin resulted in the binding of IgA-jacalin complexes to II/c GBS. This combination of nonspecific IgA and jacalin increased uptake of II/c GBS from 4.9% +/- 0.8% to 11.8% +/- 1.9% (P = 0.002). Jacalin also combined with specific, immune, monoclonal IgA bound to the surface of Haemophilus influenzae and promoted the uptake of these bacteria. Jacalin and IgA mediated phagocytosis of II/c GBS via receptors that were not dependent on divalent cations and that were not modulated by plating monocytes on antigen-antibody complexes.

100 Deals associated with Human immunoglobulin (Tonrol Biological)

Login to view more data

R&D Status

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Autoimmune Diseases	CN	Tonrol Biological Pharmaceutical Co. Ltd.	01 Jan 1998
Immunoglobulin deficiency	CN	Tonrol Biological Pharmaceutical Co. Ltd.	01 Jan 1998