Delving into the Latest Updates on Hyaluronidase(RIEMSER Pharma GmbH) with Synapse

Overview

Basic Info

Drug Type

Enzyme

Synonyms

Hylase

Target

Hyaluronic acid

Mechanism

Hyaluronic acid modulators

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

RIEMSER Pharma GmbH

Active Organization

RIEMSER Pharma GmbH

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Neoadjuvant chemotherapy with bleomycin and Cisplastin was administered on ten patients with cervical cancer (IIB, IIIA, IIIB). On three successive days, five minutes after deep bilateral subcutaneous application of 100E Hylase in the medical surface of the lower third of the shin, 20 mg/msq of bleomycin was introduced slowly. The chemotherapeutic drug was absorbed by the lymph capillaries predominantly, and then transferred to the pelvic lymph nodes. Cisplastin was administered intravenously, at a dose of 50 mg/msq. Treatment was applied three times, third week. Remission was observed in 5 out of the 10 cases.

01 Jan 1989·Zentralblatt fur Gynakologie

[Experimental studies of the prevention of postoperative adhesions].

Article

Author: Donat, H ; Schwarz, J

Female wistar rats were used for the testing of different substances to prevent postoperative intraabdominal adhesions. It could be demonstrated that the best results were obtained by dextran 70 with a concentration of 10%. Good effects were seen also by contrykal (aprotinin) and hylase (hyaluronidase). By the combination of dextran 70 30% with contrykal the spread of adhesions was very low but the effect was not significant better than with dextran 70 10% alone. For the prevention of intraabdominal adhesions operative techniques with minimal lesions are important too of the peritoneal epithelium.

01 Apr 1981·Prostaglandins and Medicine

Cervical dilatation in late first trimester termination by prostaglandin, hylase and isogel

Article

Author: U.R. Krishna ; A.V. Mandlekar ; A.C. Ganguli ; V.N. Purandare

Pre-operative dilatation of the cervix was attempted in 223 cases prior to vacuum aspiration in patients seeking late first trimester termination beyond ten weeks. 15 Me PGF2a was used in the form of vaginal suppositories, intramuscular and intracervical injections. Dilatation of cervix of 10 mm or more was achieved within 4 hours in 86% cases with intra-cervical injections. Gastro-intestinal disturbances caused by intra-muscular injections could be avoided by intra-cervical injections, as the amount of prostaglandin required was only 100 ugm, but the success rate was significantly lower. The success with multiple dose suppositories was 80%. There was no significant difference in the success with 1.5 mgm or 1.0 mgm dosage, but the side effects were significantly higher with 1.5 mgm suppositories. Intra-cervical Hylase did not dilate the cervix but successfully softened it within 5 minutes to make metallic dilatation simple. The hygroscopic Isogel tents achieved dilatation of 10 mm or more in 73% of the patients in 12 hours. The tents as well as intra-cervical prostaglandin injection had the disadvantage of requiring an additional theatre procedure prior to suction curettage.

100 Deals associated with Hyaluronidase(RIEMSER Pharma GmbH)

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