Delving into the Latest Updates on XiaoErChiQiaoQingRe with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms-

Target-

Mechanism-

Therapeutic Areas

Infectious DiseasesMouth and Tooth DiseasesOtorhinolaryngologic Diseases+ [2]

Active Indication

Common ColdFeverInfluenza, Human+ [1]

Inactive Indication-

Originator Organization

Hubei Jumpcan Pharmaceutical Co., Ltd.

Active Organization

Hubei Jumpcan Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (24 Mar 2005),

Common ColdFeverInfluenza, Human+ [1]

Regulation-

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To clarify the metabolic transformation mechanism of phenylethanoid glycosides in Xiaoer Chiqiao Qingre Granules in vivo, this study extracted and separated the phenylethanoid glycosides in Xiaoer Chiqiao Qingre Granules. Based on UPLC-Q-TOF-MS/MS technology, the retention time and primary and secondary mass spectrometry information were analyzed by UNIFI software, and 11 phenylethanoid glycosides in Xiaoer Chiqiao Qingre Granules were preliminarily identified. Sixty-nine metabolites related to phenylethanoid glycosides were identified from the plasma samples of juvenile rats after administration of Xiaoer Chiqiao Qingre Granules. In addition, this study simulated the transformation system of intestinal flora in children, and discussed the metabolic effects of intestinal flora on the representative components forsythoside A, forsythoside E, and salidroside of phenylethanoid glycosides. The model of gastrointestinal heat retention in children with food accumulation was established to study the differential metabolites of phenylethanoid glycosides. Through the comparative analysis of the representative components absorbed in blood and the intestinal floral transformation products, it was found that the main metabolic pathways of phenylethanoid glycosides were dehydrogenation, oxidation, acetylation, sulfation, and glucuronidation. The findings of this study revealed the transformation law of phenylethanoid glycosides in the gastrointestinal tract. Through the preliminary discussion of the pharmacological mechanism, this study provides references for further clarifying the pharmacodynamic material basis of Xiaoer Chiqiao Qingre Granules and exploring the pediatric Chinese medicine compound.

100 Deals associated with XiaoErChiQiaoQingRe

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Common Cold	CN	Hubei Jumpcan Pharmaceutical Co., Ltd.	24 Mar 2005
Fever	CN	Hubei Jumpcan Pharmaceutical Co., Ltd.	24 Mar 2005
Influenza, Human	CN	Hubei Jumpcan Pharmaceutical Co., Ltd.	24 Mar 2005
Pharyngitis	CN	Hubei Jumpcan Pharmaceutical Co., Ltd.	24 Mar 2005