For the Content uniformity test (CUT) of tablets where the active drug behaves in a nonaqueous medium as a base a very simple method was developed. This method is based on the extraction of the active drug from the tablet into anhydrous acetic acid and direct titration of the solute with HClO4 (0.1 or 0.05 mol/l solution in anhydrous acetic acid). The course of the titration is followed potentiometrically with a glass and calomel electrode coupled and recorded automatically with a suitable registration potentiometer. The method was successfully applied to samples of commercial tablets containing the following drugs: codeine phosphate, embramine, ephedrine, ethylmorphine, pyridoxine, thiamine and tolazoline, all as hydrochlorides. It can be used also for several other drugs.

01 Jul 1963·British Journal of Diseases of the Chest

A controlled trial of a new antihistaminic (membrophenhydramine, “Mebryl”) in the treatment of asthma

Article

Author: A.E.R. Campbell

Summary 1. A double blind trial of mebrophenydramine and an inactive preparation has been carried out on 50 asthmatic patients. The clinical impression and statistical analysis indicate that the active drug is better than placebo. 2. Thirteen of the 25 patients responded over the course of a fortnight to mebrophenhydramine and 2 of these had complete relief of symptoms. In the “placebo” group only 3 improved. 3. The only side effect reported was drowsiness which occurred in 3 patients, but the degree of this did not affect their work. 4. It is concluded that this is a useful drug with which to treat asthmatic patients and the results warrant further study in this condition.

Indian journal of dermatology, venereology and leprologyQ4 · MEDICINE

Relative Efficacy of Seven Common H1 Receptor Antagonist Antihistamines in Chronic Idiopathic Urticaria.

Q4 · MEDICINE

ArticleOA

Author: Kaur, S ; Singh, Mohan

The order of clinical potency of seven Hi receptor antagonist antihistamines in usual therapeutic doses was evaluated in 30 patients of chronic idiopathic urticaria by a double blind, placebo controlled trial utilizing a self-assessment method. The analysis of mean whealing and, itching scores established a potency sequence in the -decreasing order of cyproheptidine, hydroxyzine, chlorpheniramine, embramine, promethazine, dimeth'mdene and dexchlorpheniramme. The differences between the first five antihistamines were not statistically significant, though these were superior to ddxchlorpheniralmine and placebo. Dexchlorpheniramine was statistically better than placebo.

100 Deals associated with Embramine hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
-	Embramine hydrochloride	N05C	-

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Sedation	-	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis