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Last update 08 May 2025

Pipethanate Ethobromide

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Pipethanate, Pipethanate ethobromide (JAN), Panpurol

Target-

Action-

Mechanism-

Therapeutic Areas

Nervous System Diseases

Active Indication

Visceral spasms

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC23H30BrNO3

InChIKeyVPUGSHLBERYQGC-UHFFFAOYSA-M

CAS Registry23182-46-9

100 Clinical Results associated with Pipethanate Ethobromide

100 Translational Medicine associated with Pipethanate Ethobromide

100 Patents (Medical) associated with Pipethanate Ethobromide

Literatures (Medical) associated with Pipethanate Ethobromide

01 Oct 1992·Journal of Chromatography B: Biomedical Sciences and Applications

Determination of diphenylmethane antihistaminic drugs and their analogues in body fluids by gas chromatography with surface ionization detection

Article

Author: O. Suzuki ; H. Hattori ; T. Yamada ; M. Iwata ; S. Yamamoto ; E. Takashima

Eleven diphenylmethane antihistaminic drugs and their analogues were tested for their detection by capillary gas chromatography (GC) with surface ionization detection (SID). The GC-SID response was highest for doxylamine, diphenhydramine and orphenadrine and lowest for terodiline, clemastine and pipethanate. The detection limits for drugs with the highest response were 2-5 pg (ca. 6-20 fmol) on-column (100-250 pg/ml of body fluid). The detection limits with GC-SID were 10-100 times higher than those with GC with nitrogen-phosphorus detection. A detailed procedure for the isolation of the antihistaminics from human whole blood and urine by the use of Sep-Pak C18 cartridges, prior to GC-SID, is also presented. The recoveries of the drugs (50 or 500 pmol), which had been added to 1 ml of body fluids, were > 60%. The baselines remained steady as the column temperature was increased and the background was clean, especially for whole blood extracts.

01 Jun 1976·Archives of ToxicologyQ2 · MEDICINE

Therapeutic effects of some cholinolytics in organophosphate intoxications

Q2 · MEDICINE

Article

Author: G. Borkowska ; J. Faff ; W. Bak

The therapeutic effects of pipethanate (sycotrol) and two newly synthetized cholinolytics, DPX-8 and ANC-51, were compared with atropine in mice poisoned by DDVP, fluostigmine, phospholine, and paraoxon. The antagonistic activotagonistic activity of tested drugs against acetylcholine-induced contraction of rat ileum and oxotremorine-induced salivation and tremor in the mouse was also studied. The anticholinergic activity of pipethanate, DPX-8, and ANC-51 was weaker than that of atropine. However,the therapeutic effect of pipethanate was higher than that of atropine in mice poisoned by the organophosphates. DPX-8 and ANC-51 afforded a better antidotal effect than atropine only in DDVP-poisoned mice.

01 Jan 1971·Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences

[Studies on pharmacological effect of pipethanate. II. Effect of pipethanate on respiration, circulation system and smooth muscle].

Article

Author: Tanaka, S ; Nagao, S ; Kuwamura, T ; Kawashima, K ; Nakaura, S

100 Deals associated with Pipethanate Ethobromide

External Link

KEGG	Wiki	ATC	Drug Bank
D01987	-	A02AG	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Visceral spasms	-	-	-

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