Last update 04 Apr 2026

SIKs inhibitors-11(Hoffmann-La Roche)

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Target
SIK1 x SIK2 x SIK3
Action
inhibitors
Mechanism
SIK1 inhibitors(salt inducible kinase 1 inhibitors), SIK2 inhibitors(Serine/threonine-protein kinase SIK2 inhibitors), SIK3 inhibitors(SIK family kinase 3 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesEndocrinology and Metabolic Disease+ [1]
Active Indication
AnaphylaxisAutoimmune DiseasesInflammation+ [2]
Inactive Indication-
Originator Organization
Hoffmann-La Roche, Inc.
Active Organization
Hoffmann-La Roche, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC28H28N10O2
InChIKeyISAXEPQBJXZASC-SFHVURJKSA-N
CAS Registry3069526-04-8

Related

100 Clinical Results associated with SIKs inhibitors-11(Hoffmann-La Roche)
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100 Translational Medicine associated with SIKs inhibitors-11(Hoffmann-La Roche)
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100 Patents (Medical) associated with SIKs inhibitors-11(Hoffmann-La Roche)
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1
Literatures (Medical) associated with SIKs inhibitors-11(Hoffmann-La Roche)
12 Jun 2025ACS Medicinal Chemistry Letters
The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases
100 Deals associated with SIKs inhibitors-11(Hoffmann-La Roche)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisPreclinical
United States
Hoffmann-La Roche, Inc.
20 May 2025
Autoimmune DiseasesPreclinical
United States
Hoffmann-La Roche, Inc.
20 May 2025
InflammationPreclinical
United States
Hoffmann-La Roche, Inc.
20 May 2025
Metabolic DiseasesPreclinical
United States
Hoffmann-La Roche, Inc.
20 May 2025
NeoplasmsPreclinical
United States
Hoffmann-La Roche, Inc.
20 May 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Clinical Trial

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Approval

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Regulation

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