A polysaccharide CY-2 from C. yunnanensis was obtained through a process of consecutive water extraction, alcohol precipitation, and DEAE-52 fast-flow chromatography. CY-2, with an average molecular weight of 2.69 × 10⁴ Da mainly consisted of glucose and mannose with a molar ratio of 33.5: 56.9. Infrared spectrum (IR), methylation analysis, and nuclear magnetic resonance (NMR) results revealed that CY-2 may have a backbone consisting of →6)-α-D-Manp-(1 → 3)-β-D-Glcp-(1→, and branch chain β-D-Glcp-(1→. Meanwhile, CY-2 had a higher inhibition rate on α-glucosidase activity compared with other fractions (CY-0, CY-1, and CY-4) and was a mixed competitive inhibitor. In addition, CY-2 at the concentration of 10 μg/mL presented a superior power to improve glucose consumption and metabolism in HepG2 cells compared with metformin. Overall, these findings highlight the potential value of CY-2 as a hypoglycemic agent.

01 Feb 2023·Journal of Neurology

OnabotulinumtoxinA in elderly patients with chronic migraine: insights from a real-life European multicenter study

Article

Author: Altamura, Claudia ; Cevoli, S ; Andreou, A P ; Miscio, A M ; Torelli, P ; Negro, A ; Ahmed, F ; Silvestro, M ; Ruscheweyh, R ; Brunelli, N ; Guerzoni, S ; Gryglas-Dworak, A ; Alpuente, A ; Vernieri, F ; Latysheva, N ; Lambru, G ; Russo, M ; Martelletti, P ; Baraldi, C ; Ornello, R ; Frattale, I ; Colombo, B ; Santoro, A ; Grazzi, L ; Butera, C ; Filippi, M ; Kamm, K ; Pozo-Rosich, P ; Sacco, S ; Filatova, E ; Straburzynski, M ; Russo, A

INTRODUCTIONAlthough migraine prevalence decreases with aging, some older patients still suffer from chronic migraine (CM). This study aimed to investigate the outcome of OnabotulinumtoxinA (OBT-A) as preventative therapy in elderly CM patients.METHODSThis is a post hoc analysis of real-life prospectively collected data at 16 European headache centers on CM patients treated with OBT-A over the first three treatment cycles (i.e., Cy1-3). We defined: OLD patients aged ≥ 65 years and nonOLD those < 65-year-old. The primary endpoint was the changes in monthly headache days (MHDs) from baseline to Cy 1-3 in OLD compared with nonOLD participants. The secondary endpoints were the responder rate (RR) ≥ 50%, conversion to episodic migraine (EM) and the changes in days with acute medication use (DAMs).RESULTSIn a cohort of 2831 CM patients, 235 were OLD (8.3%, 73.2% females, 69.6 years SD 4.7). MHDs decreased from baseline (24.8 SD 6.2) to Cy-1 (17.5 SD 9.1, p < 0.000001), from Cy-1 to Cy-2 (14.8 SD 9.2, p < 0.0001), and from Cy-2 to Cy-3 (11.9 SD 7.9, p = 0.001). DAMs progressively reduced from baseline (19.2 SD 9.8) to Cy-1 (11.9 SD 8.8, p < 0.00001), to Cy-2 (10.9 SD 8.6, p = 0.012), to Cy-3 (9.6 SD 7.4, p = 0.049). The 50%RR increased from 30.7% (Cy-1) to 34.5% (Cy-2), to 38.7% (Cy-3). The above outcome measures did not differ in OLD compared with nonOLD patients.CONCLUSIONIn a population of elderly CM patients with a long history of migraine OBT-A provided a significant benefit, over the first three treatment cycles, as good as in non-old patients.

04 Sep 2013·Wei sheng wu xue bao = Acta microbiologica Sinica

[Isolation, identification and characterization of five Pseudomonas strains].

Article

Author: Li, Lanlan ; Zhang, Youming ; Ding, Xuezhi ; Zhang, Chao ; Gao, Jian ; Xia, Liqiu ; Zhang, Wangyue ; Sun, Yunjun ; Hu, Shengbiao

OBJECTIVEWe isolated Pseudomonas strains from soil samples collected from Changsha, Hunan province, catalogued them and studied the antimicrobial and antitumor activity.METHODSWe isolated Pseudomonas strains from soil samples through Galleria bait method, identified and catalogued the isolated strains according to morphological observation, physiological and biochemical characteristics and the homologous analysis of 16S rRNA sequences of nucleotides. Antimicrobial, antagonistic fungi and anti-tumor activities were studied by diffusion plate assay, dual-culture assay and cytotoxicity test respectively.RESULTSWe isolated 5 Pseudomonas strains from vegetable field and forest land of Changsha suburb, catalogued and named them as Pseudomonas protegens CY01, Pseudomonas chlororaphis CY02, Pseudomonas oryzihabitans CY04, Pseudomonas sp. CY05 and Pseudomonas putida CY06 respectively. P. protegens CY01 and P. chlororaphis CY02 have antibacterial activity against Bacillus subtillis and Staphylococcus aureus. P. chlororaphis CY02 has antagonistic activity against Pyricularia oryzae and anti-tumor cell activity against mouse melanoma B16 cells.CONCLUSIONThe isolated P. chlororaphis CY02 has a significant effect on pathogenic bacteria, Pyricularia oryzae and tumor cells.

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Indication	Highest Phase	Country/Location	Organization	Date
Epilepsy	NDA/BLA	CN	Overseas Pharmaceuticals Ltd.	12 Oct 2022

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