Last update 16 Sep 2025

TGRX-814

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TGRX 814, TGRX-814, TGRX814
Target
Bcl-2 x Bcl-xl
Action
inhibitors
Mechanism
Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors), Bcl-xl inhibitors(Apoptosis regulator Bcl-X inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesCardiovascular Diseases+ [2]
Active Indication
Acute Lymphoblastic LeukemiaChronic Lymphocytic LeukemiaMarginal Zone B-Cell Lymphoma+ [5]
Inactive Indication-
Originator Organization
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
Active Organization
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with TGRX-814
NCT06206174
/ RecruitingPhase 1/2
A Single-arm, Open-label, Dose Escalation and Expansion Phase I/II Study Evaluating Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TGRX-814 Monotherapy and Combination Therapy in Patients With Hematological Malignancies
100 Clinical Results associated with TGRX-814
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100 Translational Medicine associated with TGRX-814
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100 Patents (Medical) associated with TGRX-814
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100 Deals associated with TGRX-814
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Lymphoblastic LeukemiaPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
13 May 2024
Chronic Lymphocytic LeukemiaPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
13 May 2024
Marginal Zone B-Cell LymphomaPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
13 May 2024
Small Lymphocytic LymphomaPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
13 May 2024
Waldenstrom MacroglobulinemiaPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
13 May 2024
Acute Myeloid LeukemiaPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
06 Mar 2024
Adult Acute Lymphocytic LeukemiaPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
06 Mar 2024
Myelodysplastic SyndromesPhase 2
China
Shenzhen TargetRx, Inc.Shenzhen TargetRx, Inc.
06 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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