Last update 07 Nov 2024

MG1MA3

Overview

Basic Info

Drug Type
Recombinant vector vaccine, Shared antigen vaccine, Therapeutic vaccine
Synonyms
Marabex, AD MAGEA3, AD-MAGEA3
+ [5]
Target
MAGEA3
Mechanism
MAGEA3 inhibitors(Melanoma-associated antigen 3 inhibitors)
Therapeutic Areas
NeoplasmsRespiratory DiseasesSkin and Musculoskeletal Diseases
Active Indication-
Inactive Indication
MelanomaNon-Small Cell Lung CancerSolid tumor+ [1]
Originator Organization
McMaster UniversityMcMaster University
Active Organization-
Inactive Organization
Turnstone Biologics Corp.
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with MG1MA3
NCT03773744 / WithdrawnPhase 1
A Phase 1b, Multicenter, Open-label Trial of Oncolytic MG1 Expressing MAGE-A3 (MG1-MAGEA3) With Adenovirus Vaccine Expressing MAGE-A3 (Ad-MAGEA3), in Combination With Immune Modulating Therapy in Patients With Metastatic Melanoma or Previously Treated Cutaneous Squamous Cell Carcinoma
NCT02879760 / CompletedPhase 1/2
A Phase 1/2 Trial of MG1 Maraba Expressing MAGE-A3 (MG1-MAGEA3), With Adenovirus Vaccine Expressing MAGE-A3 (Ad-MAGEA3), in Combination With Pembrolizumab in Patients With Previously Treated Metastatic Non-Small Cell Lung Cancer (NSCLC)
100 Clinical Results associated with MG1MA3
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100 Translational Medicine associated with MG1MA3
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100 Patents (Medical) associated with MG1MA3
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100 Deals associated with MG1MA3
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2
CA
Turnstone Biologics Corp.
08 Mar 2017
Solid tumorPhase 2
CA
-22 Oct 2014
MelanomaPhase 1-
Turnstone Biologics Corp.
15 Feb 2020
Squamous Cell CarcinomaPhase 1-
Turnstone Biologics Corp.
15 Feb 2020
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Clinical Result

Indication
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Clinical Trial

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Approval

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Regulation

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