Delving into the Latest Updates on Cilostazol/Decanol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

西洛他唑/冰片

+ [1]

Target

PDE3

Mechanism

PDE3 inhibitors(Phosphodiesterase 3 inhibitors)

Therapeutic Areas

Nervous System DiseasesCardiovascular DiseasesOther Diseases

Active Indication

occlusionsReperfusion InjuryAcute Ischemic Stroke

Inactive Indication-

Originator Organization

Nanjing Ningdan New Drug Technology Co., Ltd.

Active Organization

Nanjing Ningdan New Drug Technology Co., Ltd.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure

Molecular FormulaC10H22O

InChIKeyMWKFXSUHUHTGQN-UHFFFAOYSA-N

CAS Registry112-30-1

View All Structures (2)

This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy. Moreover, we expect to evaluate the safety of using Y-6 sublingual tablet in such study population.

Start Date01 Nov 2023

Sponsor / Collaborator

Beijing Tiantan Hospital

[+1]

ChiCTR2400081678 / RecruitingPhase 2IIT

Phase clinical trial of Y-6 sublingual tablets for acute ischemic stroke —— multicenter, randomized, double-masked, placebo parallel controlled trial - FUTURE trial

Start Date13 Oct 2023

Sponsor / Collaborator-

NCT05836766 / RecruitingPhase 2IIT

Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion: A Phase Ⅱa,Prospective,Multicenter,Randomized, Double-blind,Placebo-controlled Parallel Trial

This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy. Moreover, we expect to evaluate the safety of using Y-6 sublingual tablet in such study population.

Start Date05 Jun 2023

Sponsor / Collaborator

Beijing Tiantan Hospital

[+1]

100 Clinical Results associated with Cilostazol/Decanol

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100 Translational Medicine associated with Cilostazol/Decanol

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100 Patents (Medical) associated with Cilostazol/Decanol

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23

Literatures (Medical) associated with Cilostazol/Decanol

01 Mar 2024·Small

Intermolecular Interactions, Morphology, and Photovoltaic Patterns in p–i–n Heterojunction Solar Cells With Fluorine‐Substituted Organic Photovoltaic Materials

Article

Author: Xu, Yuanjie ; Li, Qingduan ; Cai, Yue-Peng ; Huang, Fei ; Cao, Zhixiong ; Xiao, Biao ; Zhan, Xiaozhi ; Wang, Li-Ming ; Liu, Shengjian ; Sun, Yun ; Liao, Xiaolan ; Zhu, Tao

AbstractDuring the layer‐by‐layer (LBL) processing of polymer solar cells (PSCs), the swelling and molecule interdiffusion are essential for achieving precise, controllable vertical morphology, and thus efficient PSCs. However, the influencing mechanism of material properties on morphology and correlated device performance has not been paid much attention. Herein, a series of fluorinated/non‐fluorinated polymer donors (PBDB‐T and PBDB‐TF) and non‐fullerene acceptors (ITIC, IT‐2F, and IT‐4F) are employed to investigate the performance of LBL devices. The impacts of fluorine substitution on the repulsion and miscibility between the donor and acceptor, as well as the molecular arrangement of the donor/acceptor and the vertical distribution of the LBL devices are systematically explored by the measurement of donor/acceptor Flory–Huggins interaction parameters, spectroscopic ellipsometry, and neutron reflectivity, respectively. With efficient charge transfer due to the ideal vertical and horizon morphology properties, devices based on PBDB‐TF/IT‐4F exhibit the highest fill factors (FFs) as well as champion power conversion efficiencies (PCEs). With this guidance, high‐performance LBL devices with PCE of 17.2%, 18.5%, and 19.1% are obtained by the fluorinated blend of PBDB‐TF/Y6, PBDB‐TF/L8‐BO, and D18/L8‐BO respectively.

01 Jul 2023·Advanced materials (Deerfield Beach, Fla.)

Over 18% Efficiency of All-Polymer Solar Cells with Long-Term Stability Enabled by Y6 as a Solid Additive.

Article

Author: Jee, Min Hun ; Song, Jiali ; Li, Yun ; Hao, Xiaotao ; Zhang, Chen ; Qiao, Jiawei ; Fu, Zhen ; Ge, Zhongwei ; Sun, Yanming ; Woo, Han Young

Morphology control greatly influences the power conversion efficiency (PCE) and long-term stability of all-polymer solar cells (all-PSCs); however, it remains challenging owing to their complex crystallization behavior. Herein, a small amount of Y6 (2 wt%) is introduced as a solid additive into a PM6:PY-DT blend. Y6 remained inside the active layer and interacted with PY-DT to form a well-mixed phase. Increased molecular packing, enlarged phase separation size, and decreased trap density are observed for the Y6-processed PM6:PY-DT blend. The corresponding devices showed simultaneously improved short-circuit current and fill factor, achieving a high PCE of over 18% and excellent long-term stability, with a T₈₀ lifetime of 1180 h and an extrapolated T₇₀ lifetime of 9185 h at maximum power point tracking (MPP) conditions under continuous one-sun illumination. This Y6-assisted strategy is successfully applied to other all-polymer blends, demonstrating its universality for all-PSCs. This work paves a new way for the fabrication of all-PSCs with high efficiency and superior long-term stability.

01 Jun 2023·Applied microbiology and biotechnology

Response of abundance, diversity, and network of rhizosphere fungal community to monoculture of cut chrysanthemum.

Article

Author: Li, Jun ; Tao, Rui ; Hu, Baowei ; Chu, Guixin ; Ding, Wangying

The effects of different monoculture years on rhizosphere fungal communities (abundance, diversity, structure, and cooccurrence network) of cut chrysanthemum were determined. Three different monoculture years were (i) planting for only 1 year (Y1), (ii) continuous monoculture for 6 years (Y6), and (iii) continuous monoculture for 12 years (Y12). Compared to the Y1 treatment, the Y12 treatment significantly decreased the rhizosphere fungal gene copy numbers but increased the potential pathogen Fusarium oxysporum (P < 0.05). Both the Y6 and Y12 treatments significantly increased fungal diversity (Shannon and Simpson indices), but Y6 had great potential to enhance fungal richness (Chao1 index) relative to the Y12 treatment. Monoculture treatments decreased the relative abundance of Ascomycota but increased that of Mortierellomycota. Four ecological clusters (Modules 0, 3, 4, and 9) were observed in the fungal cooccurrence network across the Y1, Y6, and Y12 treatments, and only Module 0 was significantly enriched in the Y12 treatment and associated with soil properties (P < 0.05). RDA (redundancy analysis) and Mantel analysis showed that soil pH and soil nutrients (organic carbon, total nitrogen, and available phosphorus) were the key factors affecting fungal communities during monoculture of cut chrysanthemum. Overall, the changes in soil properties were responsible for shaping rhizospheric soil fungal communities in long-term rather than short-term monoculture systems. KEY POINTS: • Both short- and long-term monocultures reshaped the soil fungal community structure. • Long-term monoculture enhanced the network complexity of the fungal community. • Soil pH, C and N levels mainly drove modularization in the fungal community network.

100 Deals associated with Cilostazol/Decanol

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
occlusions	Phase 2	-	Nanjing Ningdan New Drug Technology Co., Ltd.	01 Nov 2023
Reperfusion Injury	Phase 2	-	Nanjing Ningdan New Drug Technology Co., Ltd.	01 Nov 2023
Acute Ischemic Stroke	Phase 2	CN	Nanjing Ningdan New Drug Technology Co., Ltd.	21 Apr 2023