Prospective Double-Blind Controlled Trial to Evaluate the Efficacy of Intralesional Zinc Hyaluronate Injection to Prevent Keloid Recurrence after Surgical Excision

Start Date24 Jan 2013

Sponsor / Collaborator

Faculty of Medicine

100 Clinical Results associated with Zinc hyaluronate

100 Translational Medicine associated with Zinc hyaluronate

100 Patents (Medical) associated with Zinc hyaluronate

182

Literatures (Medical) associated with Zinc hyaluronate

01 Dec 2024·International Journal of Pharmaceutics

The effect of mucoadhesive polymers on ocular permeation of thermoresponsive in situ gel containing dexamethasone–cyclodextrin complex

Article

Author: Gróf, Ilona ; Balogh, György T. ; Balogh, György T ; Deli, Mária A. ; Szalai, Boglárka ; Jójárt-Laczkovich, Orsolya ; Berkó, Szilvia ; Budai-Szűcs, Mária ; Kovács, Anita ; Katona, Gábor ; Deli, Mária A

Dexamethasone (DXM) is a commonly used corticosteroid in the treatment of ocular inflammatory conditions that affect more and more people. The aim of this study was to evaluate the effect of the combination of hydroxypropyl-β-cyclodextrin (HPBCD), in situ gelling formulations, and other mucoadhesive polymers, i.e., hydroxypropyl methylcellulose (HPMC) and zinc-hyaluronate (ZnHA), on permeation by applying in vitro and ex vivo ophthalmic permeation models. Additionally, gelling properties, in vitro drug release, and mucoadhesion were measured to determine the impact of these factors on permeation and ultimately on bioavailability. The results showed that GEL1 and GEL2 had an optimal gelling temperature, 36.3 ℃ and 34.6 ℃, respectively. Moreover, the combination of Poloxamer 407 (P407) with other polymers improved the mucoadhesion (GEL1: 1333.7 mN) compared with formulations containing only P407 (P12: 721.8 mN). Both HPBCD and the gel matrix had a considerable influence on the drug release and permeability of DXM, and the combination could facilitate the permeation into the aqueous humor. After 30 min of treatment, the DXM concentration in the aqueous humor was 1.16-1.37 µg∕mL in case of the gels, whereas DXM could not be detected when treated with the DXM suspension. The results of the experiments using an in vitro cell line indicated that the formulations could be considered safe for topical treatment of the eye. In conclusion, with application of a small amount of HPMC (0.2 % w∕w), the concentration of P407 could be reduced to 12 % w/w while maintaining the ideal gelling properties and gel structure without negatively affecting permeability compared with the formulation containing a higher amount of P407. Furthermore, the gel matrix may also provide programmed and elongated drug release.

01 Oct 2024·Odontology

Effect of cement type on vertical marginal discrepancy and residual excess cement in screwmentable and cementable implant-supported monolithic zirconia crowns

Article

Author: Yıldız, Pınar ; Talay Çevlik, Esra ; Alkan Demetoğlu, Göknil

The purpose of this study was to investigate the vertical marginal discrepancy (VMD) and residual excess cement (REC) of cementable and screwmentable monolithic zirconia crowns cemented with different types of cement. Abutments were attached to 40 implant analogues. Crowns were created using computer-aided design/computer-aided manufacturing technology from monolithic zirconia blocks, either with or without a screw access hole (SAC). Crowns created both ways were split into two groups and cemented with resin and zinc polycarboxylate cement under a 5-kg weight. VMD and REC values were evaluated using an X20 zoom stereomicroscope. Data were analysed using two-way ANOVA and the Bonferroni test. According to the two-way ANOVA results, REC measurements differed significantly in the crown design and cement groups. However, whilst VMD values were significantly different in both crown design groups, there was no significant difference in the cement groups. According to the Bonferroni test results, the highest REC (157.241 ± 44.29 µm) and VMD (68.052 ± 16.19 µm) values were found in the crowns without SAC and cemented with zinc polycarboxylate. Screwmentable crowns are more effective than cementable crowns in reducing REC and VMD. Whilst polycarboxylate cement reduces VMD in screwmentable crowns, resin cement is more suitable for cementable crowns.

16 Sep 2024·Materials (Basel, Switzerland)

Boosting Flame Retardancy of Polypropylene/Calcium Carbonate Composites with Inorganic Flame Retardants.

Article

Author: Mapossa, Antonio Benjamim ; Sundararaj, Uttandaraman ; Dos Anjos, Erick Gabriel Ribeiro

This study investigates the effects of inorganic flame retardants, zinc borate, and magnesium hydroxide, on the thermal, morphological, flame retardancy, and mechanical properties of polypropylene (PP)/calcium carbonate composites for potential construction industry applications. Polypropylene/calcium carbonate (50 wt.%) composites containing 5 and 10 wt.% flame retardants were prepared using a batch mixer, followed by compression moulding. The results demonstrated enhanced thermal stability, with the highest char residue reaching 47.2% for polypropylene/calcium carbonate/zinc borate (10 wt.%)/magnesium hydroxide (10 wt.%) composite, a notably strong outcome. Additionally, the composite exhibited an elevated limited oxygen index (LOI) of 29.4%, indicating a synergistic effect between zinc borate and magnesium hydroxide. The proposed flame retardancy mechanism suggests that the flammability performance is driven by the interaction between the flame retardants within the polypropylene/calcium carbonate matrix. Magnesium hydroxide contributes to smoke suppression by releasing water, while zinc borate forms a protective glassy foam that covers the burning surface, promoting char formation and acting as a physical barrier to heat transmission and fire spread. Scanning electron microscopy confirmed good dispersion of the additives alongside calcium carbonate within the polymer matrix. Despite the addition of up to 10 wt.% flame retardants, the composites maintained high-notched impact strength.

100 Deals associated with Zinc hyaluronate

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Pubmed \| Am J Ophthalmol	Not Applicable	Dry Eye Syndromes	20	0.15% zinc-hyaluronate	(kolnlapcut) = iklwvmsrtq keilzblqlv (azgiydkhoj )	-	01 Jan 2017

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