2
Clinical Trials associated with Fecal Microbial Transplantation(Beth Israel Deaconess Medical Center)NCCH2308 Safety study of intestinal microbiota following combination therapy with fecal microbial transplantation and antibiotics for patietnts with esophageal cancer and gastric cancer treated with immune checkpoint Inhibitors
Start Date18 Jun 2024 |
Sponsor / Collaborator- |
Impact of Fecal Biotherapy (FBT) on Microbial Diversity in Patients With Moderate to Severe Inflammatory Bowel Disease
The human immune system is usually tolerant of the millions of beneficial commensal bacteria (the microbiome), which colonize the healthy intestinal tract. In contrast, patients with Inflammatory Bowel Disease (IBD) may play host to an imbalanced mix of such intestinal bacteria, which initiates abnormal immune responses in susceptible individuals. The resulting inflammation that occurs in the gastrointestinal tract damages the intestinal lining, leading to symptoms (such as intractable diarrhea, pain or weight loss), heightened cancer risk, other serious complications with substantial morbidity and even death. Current therapies for IBD focus on suppressing the excessive immune response to these bacteria, but have major side effects and do not address any role of the microbiome in disease development.
The investigators hypothesize that there is heightened intraluminal generation of pro-inflammatory factors by luminal "pathogenic" bacteria, such as extracellular nucleotides and purinergic derivatives, which trigger host immune cells. This results in loss of suppressive T regulatory cells with unrestrained immune cell deviation to pathogenic T helper cells that cause inflammatory responses. The investigators' proposal is that correcting the disease-provoking microbiome would beneficially improve gut microbial diversity, alter immune responses elicited in patients by such microbial products of pathogenic bacteria, and ultimately limit and suppress disease activity.
To test the hypothesis, the investigators propose to enroll patients with active Crohn's Disease, and introduce the microbiome of healthy and unrelated individuals to patient's intestinal tract, via fecal biotherapy (FBT) with all applicable safety measures. The investigators propose to comprehensively test the effects of FBT on the host microbiome, determine microbial production of inflammatory nucleotides and derivatives, which the investigators suggest might impact the host immune response and disease activity in patients with IBD.
100 Clinical Results associated with Fecal Microbial Transplantation(Beth Israel Deaconess Medical Center)
100 Translational Medicine associated with Fecal Microbial Transplantation(Beth Israel Deaconess Medical Center)
100 Patents (Medical) associated with Fecal Microbial Transplantation(Beth Israel Deaconess Medical Center)
100 Deals associated with Fecal Microbial Transplantation(Beth Israel Deaconess Medical Center)