Last update 25 Oct 2025

TIL 1383I TCR transduced T cells(NCI)

Overview

Basic Info

Drug Type
TCR-T Cell therapy
Synonyms-
Target
TYR
Action
inhibitors
Mechanism
TYR inhibitors(Tyrosinase inhibitors)
Therapeutic Areas
NeoplasmsSkin and Musculoskeletal Diseases
Active Indication
Metastatic melanoma
Inactive Indication-
Originator Organization
Loyola University Medical Center
Active Organization
Loyola University Medical Center
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with TIL 1383I TCR transduced T cells(NCI)
NCT02870244
/ RecruitingPhase 1IIT
Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes: A Phase 1b Study
NCT01586403
/ Active, not recruitingPhase 1IIT
Transfer of Genetically Engineered Lymphocytes in Melanoma Patients: A Phase 1 Dose Escalation Study
100 Clinical Results associated with TIL 1383I TCR transduced T cells(NCI)
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100 Translational Medicine associated with TIL 1383I TCR transduced T cells(NCI)
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100 Patents (Medical) associated with TIL 1383I TCR transduced T cells(NCI)
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100 Deals associated with TIL 1383I TCR transduced T cells(NCI)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic melanomaPhase 1
United States
Loyola University Medical Center
01 Jul 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
LU 203732 (SITC2015)
Phase 1
Melanoma
HLA-A2 | tyrosinase
24
genetically engineered lymphocytes
(Genetically engineered TIL 1383I TCR transduced T cells)
ipnbvyxthp(orbyrjargy) = jqdmwxjfyh jbnrlejpfn (pbkjvbtxfi )
Positive
04 Nov 2015
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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