Tuberculosis (TB), an infectious remains a global health burden till date.Considering immense importance of theor. tools in computer aided-drug designing, the current study focuses on common pharmacophore and QSAR anal. of 38 imidazopyridine analogs as anti-TB agents.Our developed atom-based, field-based, and multilinear regression based-QSAR models showed high values for statistical robustness for internal as well as external validations (a correlation coefficient: R2 > 0.9, least standard deviations, higher Fischer coefficient, and cross-validation correlation coefficient: Q2 > 0.5).From our ZINC-Drug-like anal., we were retained with 5 hits (VS1-VS-5), among them VS-4 mol. was found to have high potency (predicted pIC50 (μM) value: 7.96 (against MTB H37Rv ATCC 27,294)) with good theor. properties (high softness, and low hardness values).From our designed analogs (S1-S10), analog S-10 was retained with high potency as well as good pharmacokinetics to act as good anti-mycobacterial agent in future.