100 Clinical Results associated with Chk1 degraders PROTAC-2
100 Translational Medicine associated with Chk1 degraders PROTAC-2
100 Patents (Medical) associated with Chk1 degraders PROTAC-2
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Literatures (Medical) associated with Chk1 degraders PROTAC-2bioRxiv : the preprint server for biology
Development of a PROTAC Targeting Chk1
Author: Statsyuk, Alexander ; Mgbemena, Victoria E ; Chowdhury, Sandipan Roy ; Chuong, Patrick
A series of Chk1 degraders were designed and synthesized. The degraders were developed through the conjugation of a promiscuous kinase binder and thalidomide. One of the degraders PROTAC-2 was able to decrease Chk1 levels in a concentration-dependent manner in A375 cells. The developed probes can be useful for the development of selective and more potent Chk1 degraders.
100 Deals associated with Chk1 degraders PROTAC-2