Delving into the Latest Updates on DS-108 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Mechanism-

Therapeutic Areas

Immune System DiseasesSkin and Musculoskeletal Diseases

Active Indication-

Inactive Indication

Immune System DiseasesSkin Diseases

Originator Organization

Dignity Sciences Ltd.

Active Organization-

Inactive Organization

Dignity Sciences Ltd.

Drug Highest PhaseDiscontinuedDiscovery

First Approval Date-

Regulation-

AbstractNeuropilin‐1 (NRP1) is emerging as an important molecule in immune signaling where it has been shown to modulate the actions of TGF‐β1 in macrophages and regulatory T cells. The development of cost‐effective and reliable assays for NRP1 binding is therefore important. We synthesized three new NRP1 small molecule fluorophores and examined their performance as fluorescent polarization probes. One molecule DS108 exhibited favorable binding and fluorescent characteristics and allowed us to establish a simple assay suitable for medium to high throughput screening of small molecules.

100 Deals associated with DS-108

Login to view more data