CONTEXTIn Japan, many patients who cannot consume food orally are managed using external tube feeding over long periods. Although helpful in nutritional management, tube feeding significantly reduces a patient's quality of life.AIMSWe examined the factors that affected the transition from tube to oral feeding in elderly people.SETTINGS AND DESIGNSingle-center, retrospective, pilot study conducted from January 1, 2018 to December 28, 2019.METHODS AND MATERIALSWe recruited patients who attempted to return to oral intake following tube feeding for >12 months at Miyama Hospital. Fourteen participants (male-to-female ratio = 6:8; age = 83.9 ± 2.6 years) attempted to resume oral feeding. We investigated patient diagnoses, duration of tube feeding, sex, swallowing reflex time, and Kohnan consciousness score. Patients with a swallowing reflex >4 s were administered banxia houpu tang.RESULTSOf the 14 patients, seven managed to resume oral feeding (group 1), while the remaining seven failed (group 2). The two groups of patients showed no significant difference in terms of mean age, duration of tube feeding, swallowing reflex time, and sex. However, the consciousness level of group 1 was significantly higher than that of group 2.CONCLUSIONSHigher consciousness level in patients who successfully resumed oral feeding suggests that oral feeding should be considered in patients with adequate consciousness.

15 Apr 2016·China Journal of Chinese Materia Medica

Nuclear magnetic resonance-based metabonomics for sedative and hypnotic effect of Banxia Houpo decoction

Article

Author: Yang, Jian-Yun ; Xiao, Bing-Kun ; Guo, Chun-Hua ; Liu, Shao-Lei ; Huang, Rong-Qing ; Shen, Shu-Jie

Insomnia was a common disease, which might be correlated with γ-aminobutyric acid A (GABAA) receptor mechanism, cytokine regulatory mechanism, excitatory amino acid mechanism and hydroxytryptamine (5-HT) receptor mechanism, but the correlations between these independent mechanisms and pathological characterization were still unclear. To further explore the effect of Banxia Houpo decoction on known or unknown biological pathways during treatment of insomnia, the metabonomics method based on ¹H-NMR was developed for detecting the significant changes in metabolomics after the administration with Banxia Houpo decoction in pentobarbital sodium-induced rat sleeping experiment. Serum and urine samples were analyzed by ¹H-NMR. Principal component analysis (PCA) was carried out for endogenous small molecule metabolites in urine and serum. H-NMR spectroscopies and relevant metabolites were found and identified by Simca-p 17.0 (Umet-rics, Umea, Sweden) and Chenomx NMR Suite 7.1 (Chenomx, Inc., Edmonton, Alberta, Canada) software. The result suggests that Banxia Houpo decoction group and indiplon group had significant differences. The load diagram showed the biggest variation metabolites and intergroup significant differences among 10 metabolic substances. According to the experiment, Banxia Houpo decoction group and indiplon group can prolonge the sleeping time of pentobarbital sodium-induced sprague-dawley rats, with a synergistic effect. The significant changes of these biomarkers indicated that the Banxia Houpo decoction could aid sleep by adjusting the content of glutamine, creatine phosphate, 2-oxoglutarate, and reducing the activity of brain nerves.

100 Deals associated with Banxia Houpo Decoction

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Indication	Country/Location	Organization	Date
Gastritis	Japan	Kowa Yakutsu Y.K.	02 Sep 1986
Anxiety Disorders	Japan	Ohsugi Pharmaceutical Co., Ltd.	22 Aug 1986
Cough	Japan	Ohsugi Pharmaceutical Co., Ltd.	22 Aug 1986
Asthma	Japan	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Bronchitis	Japan	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Hoarseness	Japan	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Whooping Cough	Japan	Sanwa Shoyaku Co., Ltd.	18 Jul 1986

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