AbstractExperiments have been carried out in dogs and man to determine the effect of hydrochlorothiazide (HCT) on the pharmacokinetics of propranlol and to evaluate the bioavailability of two dosage forms containing both propranolol and HCT (40/25 and 80/25 mg, respectively). In adult male beagles, 50 mg of HCT had no apparent effect on AUC, Cmax, Tmax, and T1/2 of propranolol administered concurrently. In man, INDERIDE® (40/25 mg) and INDERIDE® (80/25 mg) were shown to be similar in bioavailability to the reference formulations, i.e. the same amount of drugs administered as the separate tablets of INDERAL® plus HYDRODIURIL®.

World Journal of Pharmaceutical Research

Method development and validation of some antihypertensive drugs with hydrochlorothiazide by reversed-phase high-performance liquid chromatography

Author: Ameta, Suresh Chanda ; Kothari, Seema ; Mehta, Mayank ; Pandya, Pranav ; Patel, Mohini A.

A simple, reliable, specific, accurate, and precise reversed-phase high-performance liquid chromatog. method was developed and validated for simultaneous estimation of atenolol, metoprolol, propranolol with hydrochlorothiazide in pharmaceutical dosage form.Chromatog. separation was carried out on Agilent HPLC 1200 series bridge C18 column (Xbridge C18, size: 250 mm x 4.60 mm, particle size 5μm) with a mobile phase (0.1% formic acid in water and acetonitrile) with gradient mode of a flow rate of 1 mL/min.The detection was monitored at 228 nm., and the method was found applicable in the concentration range of 10 to 90%.The proposed method was successfully applied for quant. determination of atenolol, metoprolol, propranolol with hydrochlorothiazide in dosage form.The retention times of Atenolol, metoprolol, propranolol and hydrochlorothiazide were found to be 7.230,6.477,4.123 and 1.368min resp. theor. plate count as per ICH limits.The limit of detection is achieved on the lowest level for making a sensitive and robust method for simultaneous and assay anal.The Rp-HPLC method was validated and was successfully employed for the anal. of pharmaceutical formulations containing Atenolol, metoprolol, propranolol and Hydrochlorothiazide in combined tablet dosage form.

100 Deals associated with Hydrochlorothiazide/Propranolol Hydrochloride

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