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Last update 08 May 2025

Sulfaguanidine

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Sulfaguandine, Sulfaguanidine, Sulfaguanidine (INN)

+ [8]

Target

Folate

Action

inhibitors

Mechanism

Folate inhibitors

Therapeutic Areas

Digestive System Disorders

Active Indication

DysenteryEnteritis

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC7H10N4O2S

InChIKeyBRBKOPJOKNSWSG-UHFFFAOYSA-N

CAS Registry57-67-0

100 Clinical Results associated with Sulfaguanidine

100 Translational Medicine associated with Sulfaguanidine

100 Patents (Medical) associated with Sulfaguanidine

2,689

Literatures (Medical) associated with Sulfaguanidine

01 Jul 2025·Food Chemistry

Spectrophotofluorometric assay of Sulfaguanidine in Milk whey

Article

Author: Chaydonova, Vlada ; Bryantseva, Natalia ; Bocharnikova, Elena ; Avramov, Pavel ; Tchaikovskaya, Olga

The methylene blue fluorescence quenching and bromocresol purple spectrophotometric methods were applied to achieve the detection of sulfaguanidine in whey. The quenching of the fluorescence marker by sulfaguanidine in whey was used to elucidate the effect of the quencher on the Stern-Volmer quenching constant (K_SV) values. The interaction of methylene blue with sulfaguanidine increases in whey by 3 times compared to water (K_SV = 3 × 10³ M^-1 and K_SV = 1 × 10³ M^-1, respectively). The value of the Stern-Volmer quenching constant K_SV = 4 × 10⁴ M^-1 is the highest for quenching of whey fluorescence by bromocresol purple. The obtained results were applied as a spectral method for determining the concentration of sulfaguanidine in whey. Analytic emission (348, 430 and 700 nm) and absorption (259, 435 and 590 nm) wavelengths were used. The concentration for detecting sulfaguanidine in whey was 5 × 10^-7 M (0.01 mg/mL) which is an order of magnitude lower the limit of spectrophotometric method.

01 Jun 2025·Journal of Hazardous Materials

Simultaneous and instrument-free detection of quinine and crystal violet based on a dual-emissive Eu3+-functionalized metal-organic framework

Article

Author: Xia, Yi-Fan ; Fu, Jia-Hao ; Yuan, Yuan ; Bao, Guang-Ming ; Chen, Peiyao ; Pan, Meng-Yuan ; Yuan, Hou-Qun ; Jiang, Lirong ; Liu, Si-Yi ; Li, Wei

Simultaneous detection and quantification of multi-targets is a challenge using one single sensor in the complicated environment of real samples. Herein, we developed a dual-emissive sensor (EuUCHNA) that selectively and rapidly responds to crystal violet (CV) and quinine (QN), two commonly used anti-infective drugs for fungi, bacteria, and parasites, through distinct responsive modes. CV can effectively quench the blue and red fluorescent emission bands of EuUCHNA. By contrast, QN can remarkably enhance the blue emission band. The limit of detection (LOD) for CV and QN are 2.4 nM and 32.0 nM, respectively, which are superior to most of the reported sensors. EuUCHNA has been used to determine CV and QN in fish meat and fish pond water with good performance. Moreover, CV and QN can be simultaneously quantified by EuUCHNA in practical fish pond water. Furthermore, we constructed an instrument-free detection method via a smartphone with a color recognition app, which was successfully employed to detect CV and QN in fish pond water. This work provides a promising fluorescent sensor and a new analytical method for the simultaneous quantification of two targets in real samples using a single sensor.

01 Jun 2025·Separation and Purification Technology

Thiol-yne click postsynthesis of imidazole-functionalized cyclodextrin microporous organic network: A remarkable adsorbent for sulfonamide antibiotics

Author: Yang, Cheng-Xiong ; Wang, Ting ; Yue, Yun-Da ; Cui, Yuan-Yuan

Sulfonamides (SAs) are widely used broad-spectrum antibiotics for treating infections.However, their inevitable residues pose serious threats to human health and agroecosystems.Hence, reasonable design and synthesis efficient adsorbents to remove residual SAs from the environment are crucial and highly desired.In this study, a novel imidazole-functionalized cyclodextrin-based microporous organic network (α-CD-MON-BZ) was designed and synthesized through the specific thiol-yne click post-modification for the efficient removal of SAs.The prepared α-CD-MON-BZ exhibited ultrafast adsorption kinetics (<3 min) and an exceptionally high saturation adsorption capacity (571.4 mg/g) for sulfamethoxypyridazine (SMP).This capacity was much higher than those of other reported adsorbents.Fourier transform IR spectroscopy, XPS, and d. functional theory calculations revealed that the adsorption process involves hydrophobic, π-π, hydrogen bonding, host-guest, and electrostatic interactions.Furthermore, α-CD-MON-BZ exhibited favorable reusability and selectivity.This study introduces a new method to construct novel functionalized CD-MONs for highly efficient SAs removal and promotes the design and applications of such materials in contaminant removal.

100 Deals associated with Sulfaguanidine

External Link

KEGG	Wiki	ATC	Drug Bank
D02437	Sulfaguanidine	A07AB03	DB13726

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Dysentery	-	-	-
Enteritis	-	-	-

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