Up to a third of patients who recovered from SARS coronavirus (SARS-CoV) had a 20% decline in lung function with a long term reduction in exercise capacity and SF-36 health status a year after infection. Similar outcomes are now being reported in COVID-19 patients, with interstitial lung disease (fibrosis) and long term lung function decline being a common feature. Anti-fibrotic monocytes/macrophages are important for the clearance of partially degraded collagen fragments of fibrotic extracellular matrix, in particular fibrillary-type collagen.
MON002 is an autologous monocyte product, cultured in vitro prior to intravenous delivery into patients with post-COVID-19 lung fibrosis.

Start Date08 Mar 2021

Sponsor / Collaborator

Guy's & St Thomas' Charity

[+1]

100 Clinical Results associated with MON002

100 Translational Medicine associated with MON002

100 Patents (Medical) associated with MON002

Literatures (Medical) associated with MON002

18 Jan 2010·Inorganic ChemistryQ2 · CHEMISTRY

Formation of {[HIPTN₃N]Mo(III)H}⁻by Heterolytic Cleavage of H₂as Established by EPR and ENDOR Spectroscopy

Q2 · CHEMISTRY

Article

Author: Hetterscheid, Dennis G. H. ; Hoffman, Brian M. ; Schrock, Richard R. ; Kinney, R. Adam ; Hanna, Brian S.

MoN(2) (Mo = [(HIPTNCH(2)CH(2))(3)N]Mo, where HIPT = 3,5-(2,4,6-i-Pr(3)C(6)H(2))(2)C(6)H(3)) is the first stage in the reduction of N(2) to NH(3) by Mo. Its reaction with dihydrogen in fluid solution yields "MoH(2)", a molybdenum-dihydrogen compound. In this report, we describe a comprehensive electron paramagnetic resonance (EPR) and (1/2)H/(14)N electron nuclear double resonance (ENDOR) study of the product of the reaction between MoN(2) and H(2) that is trapped in frozen solution, 1. EPR spectra of 1 show that it has a near-axial g tensor, g = [2.086, 1.961, 1.947], with dramatically reduced g anisotropy relative to MoN(2). Analysis of the g values reveal that this anion has the Mo(III), [d(xz), d(yz)](3) orbital configuration, as proposed for the parent MoN(2) complex, and that it undergoes a strong pseudo-Jahn-Teller (PJT) distortion. Simulations of the 2D 35 GHz (1)H ENDOR pattern comprised of spectra taken at multiple fields across the EPR envelope (2 K) show that 1 is the [MoH](-) anion. The 35 GHz Mims pulsed (2)H ENDOR spectra of 1 prepared with (2)H(2) show the corresponding (2)H(-) signal, with a substantial deuterium isotope effect in a(iso). Radiolytic reduction of a structural analogue, Mo(IV)H, at 77 K, confirms the assignment of 1. Analysis of the 2D (14)N ENDOR pattern for the ligand amine nitrogen further reveals the presence of a linear N(ax)-Mo-H(-) molecular axis that is parallel to the unique magnetic direction (g(1)). The ENDOR pattern of the three equatorial nitrogens is well-reproduced by a model in which the Mo-N(eq) plane has undergone a static, not dynamic, PJT distortion, leading to a range of hyperfine couplings for the three N(eq)'s. The finding of a nearly axial hyperfine coupling tensor for the terminal hydride bound Mo supports the earlier proposal that the two exchangeable hydrogenic species bound to the FeMo cofactor of the nitrogense turnover intermediate, which has accumulated four electrons/protons (E(4)), are hydrides that bridge two metal ions, not terminal hydrides.

01 Mar 2009·Journal of vector borne diseasesQ4 · MEDICINE

Is leishmaniasis in Sri Lanka benign and be ignored?

Q4 · MEDICINE

ReviewOA

Author: Rajapaksa, U S ; Karunaweera, N D

Cutaneous leishmaniasis is now an endemic disease in Sri Lanka. Many studies have focussed on various aspects of this disease but the knowledge, particularly on epidemiological and vector aspects is still poor and the awareness among the general public and even medical/paramedical personnel regarding this disease remains grossly inadequate. The steady increase in the numbers and spread of cutaneous leishmaniasis cases in Sri Lanka and the very close similarity (genotypic and phenotypic) between the local parasite Leishmania donovani MON-37 and the parasite causing visceral leishmaniasis in India (L. donovani MON-2), considered together with the more recent case reports of autochthonous cases of visceral disease in this country, calls for urgent action for setting up of a surveillance programme to estimate the true disease burden and to implement an organized control strategy, combined with operational and epidemiological research to aid control efforts to avert a potentially major catastrophe of more virulent form of leishmaniasis, particularly the visceral type becoming endemic in Sri Lanka.

Dalton Trans.Q2 · CHEMISTRY

An electrochemical investigation of intermediates and processes involved in the catalyticreduction of dinitrogen by [HIPTN3N]Mo (HIPTN3N = (3,5-(2,4,6-i-Pr3C6H2)2C6H3NCH2CH2)3N)

Q2 · CHEMISTRY

Article

Author: Schrock, Richard R. ; Munisamy, Thiruvengadam

The redox properties of [HIPTN(3)N]Mo complexes (where HIPTN(3)N = (3,5-(2,4,6-i-Pr(3)C(6)H(2))(2)C(6)H(3)NCH(2)CH(2))(3)N) involved in the catalytic dinitrogen reduction cycle were studied using cyclic voltammetry in fluorobenzene with Bu(4)NPF(6) as the electrolyte. MoN(2) (Mo = [HIPTN(3)N]Mo, E(1/2) = -1.96 V vs. Fc(+)/Fc at a Pt electrode), Mo≡N (E(1/2) = -2.68 V vs. Fc(+)/Fc (Pt)), and [Mo(NH(3))]BAr'(4) (Ar' = 3,5-(CF(3))(2)C(6)H(3), E(1/2) = -1.53 V vs. Fc(+)/Fc (Pt)) each undergo a chemically reversible one-electron reduction, while [Mo=NNH(2)]BAr'(4) (E(1/2) = -1.50 V vs. Fc(+)/Fc (Pt)) and [Mo=NH]BAr'(4) (E(1/2) = -1.26 V vs. Fc(+)/Fc (Pt)) each undergo a one-electron reduction with partial chemical reversibility. The acid employed in the catalytic reduction, [2,4,6-collidinium]BAr'(4), reduces irreversibly at -1.11 V vs. Fc(+)/Fc at Pt and at -2.10 V vs. Fc(+)/Fc at a glassy carbon electrode. The reduction peak potentials of the Mo complexes shift in the presence of acids. For example, the reduction peak for MoN(2) in the presence of [2,4,6-collidinium]BAr'(4) at a glassy carbon electrode shifts positively by 130 mV. The shift in reduction potential is explained in terms of reversible hydrogen bonding and/or protonation at a nitrogen site in Mo complexes. The significance of productive and unproductive proton-coupled electron transfer reactions in the catalytic dinitrogen reduction cycle is discussed.

100 Deals associated with MON002

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Indication	Highest Phase	Country/Location	Organization	Date
COVID-19	Phase 2	GB	Guy's & St Thomas' Charity	08 Mar 2021
Pulmonary Fibrosis	Phase 2	GB	Guy's & St Thomas' Charity	08 Mar 2021

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