The effect of hydroalcoholic extract of Nasturtium officinale on level of vitamin C and E, protein carbonyl and inflammatory markers in chronic hemodialysis patients.

Start Date20 Jan 2021

Sponsor / Collaborator-

IRCT20200322046834N1 / SuspendedPhase 3IIT

Assessment of E & C vitamins effects on oxidative stress biomarkers, biochemical parameters, Depression, anxiety and stress in workers exposed to noise, cement dust and silica in SHIRAZ cement plant.

Start Date20 Jul 2020

Sponsor / Collaborator

Shiraz University of Medical Sciences

IRCT20180425039414N3 / CompletedPhase 2/3IIT

The effect of vitamin C and E in the treatment and clinical course of patients with SARS-cov2 (COVID-19)

Start Date20 Apr 2020

Sponsor / Collaborator

Isfahan University of Medical Sciences

100 Clinical Results associated with Vitamin E/Ascorbic Acid

100 Translational Medicine associated with Vitamin E/Ascorbic Acid

100 Patents (Medical) associated with Vitamin E/Ascorbic Acid

Literatures (Medical) associated with Vitamin E/Ascorbic Acid

01 Aug 2020·Journal of BiotechnologyQ3 · ENGINEERING & TECHNOLOGY

Pathway engineering and medium optimization for α-farnesene biosynthesis in oleaginous yeast Yarrowia lipolytica

Q3 · ENGINEERING & TECHNOLOGY

Article

Author: Hua, Qiang ; Liu, Shun-Cheng ; Liu, Zhijie ; Wei, Liu-Jing

Farnesene is a typical sesquiterpene with applications as fragrance, flavor and precursor for the synthesis of vitamin E/K1. In this study, a series of strategies were employed to facilitate α-farnesene accumulation in Yarrowia lipolytica. Among them, the promoter optimization of OptFSLERG20, Sc-tHMG1 and IDI resulted in more than 62 % increase in α-farnesene production. Together with the overexpression of Yl-HMGR and ERG19, α-farnesene content was significantly improved by more than 3.5 times. The best metabolic engineered strain obtained was therefore used for a uniform design in shake flasks to determine the optimal medium compositions. Furthermore, a maximum α-farnesene production of approximately 2.57 g/L (34 mg/g DCW) was obtained in fed-batch fermentation where glycerol was supplemented as the feeding carbon source when initial glucose was depleted. This study has laid a good foundation for the development of Y. lipolytica as a promising chassis microbial cell for heterologous biosynthesis of α-farnesene and other sesquiterpenes.

01 Sep 2016·Otolaryngology–Head and Neck SurgeryQ2 · MEDICINE

Randomized Trial of Vitamin C/E Complex for Prevention of Radiation‐Induced Xerostomia in Patients with Head and Neck Cancer

Q2 · MEDICINE

Article

Author: Chung, Man Ki ; Ahn, Yong Chan ; Kim, Do Hun ; Kim, Eun Hye ; Choi, Joon Young ; Son, Young‐Ik

ObjectiveThe present study was conducted to determine the preventive efficacy of vitamin C/E complex supplementation for radiotherapy (RT)–induced xerostomia in patients with head and neck cancer.Study DesignProspective, double‐blinded, randomized, placebo‐controlled study.SettingA single tertiary referral institution.Subjects and MethodsThe trial group (n = 25) received antioxidant supplements (100 IU of vitamin E + 500 mg of vitamin C) twice per day during RT, while the control group (n = 20) received an identical placebo. Pre‐RT and 1 and 6 months post‐RT, patient‐reported xerostomia questionnaires, observer‐rated xerostomia score, and salivary scintigraphy were serially obtained to compare xerostomia severity between the 2 groups.ResultsThe trial group showed greater improvements in xerostomia questionnaire and score at 6 months post‐RT when compared with those at 1 month post‐RT (P =. 007 and. 008, respectively). In contrast, the control group showed no changes between 1 and 6 months post‐RT. By salivary scintigraphy, there was no difference in maximal accumulation or ejection fraction between the 2 groups. However, the trial group maintained significantly better oral indices at the prestimulatory (P =. 01) and poststimulatory (P =. 009) stages at 1 month post‐RT, compared with the control group. At the final follow‐up, there was no difference in overall survival and disease‐free survival between the 2 groups.ConclusionsOur data suggest that short‐term supplementation with an antioxidant vitamin E/C complex exerts a protective effect against RT‐induced xerostomia.

100 Deals associated with Vitamin E/Ascorbic Acid

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Indication	Highest Phase	Country/Location	Organization	Date
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