Last update 21 Nov 2024

Indometacin/L-menthol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
L-Menthol/Indometacin
Target
COX x TRPA1 x TRPM8 x κ opioid receptor
Mechanism
COX inhibitors(Cyclooxygenases inhibitors), TRPA1 inhibitors(Transient receptor potential cation channel subfamily A member 1 inhibitors), TRPM8 agonists(Transient receptor potential cation channel subfamily M member 8 agonists)
+ [1]
Therapeutic Areas
Nervous System DiseasesSkin and Musculoskeletal Diseases
Active Indication-
Inactive Indication
Acute PainMyalgia
Originator Organization
Kowa Co., Ltd.Kowa Co., Ltd.
Active Organization-
Inactive Organization
Kowa Research Institute, Inc.
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC19H16ClNO4
InChIKeyCGIGDMFJXJATDK-UHFFFAOYSA-N
CAS Registry53-86-1
View All Structures (2)

Related

2
Clinical Trials associated with Indometacin/L-menthol
NCT04484428 / TerminatedPhase 2
A Phase II, Randomized, Double-blind, Active Comparator, Parallel Group Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed Onset Muscle Soreness (DOMS) in the Lower Extremity
NCT03712241 / CompletedPhase 1
A Phase I, Open-label, Randomized, 4-period Crossover Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of K-285 Compared With a Single Oral Dose of Indomethacin Capsule in Healthy Adult Volunteers
100 Clinical Results associated with Indometacin/L-menthol
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100 Translational Medicine associated with Indometacin/L-menthol
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100 Patents (Medical) associated with Indometacin/L-menthol
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100 Deals associated with Indometacin/L-menthol
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute PainPhase 2
US
Kowa Research Institute, Inc.
15 Aug 2020
MyalgiaPhase 2
US
Kowa Research Institute, Inc.
15 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Clinical Trial

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Approval

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Regulation

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