Background:This study evaluates the efficacy of a novel bismuth subgallate-borneol compound ointment as an adjuvant therapy in promoting postoperative healing of infectious incisions after anorectal surgery.Methods:From June 2023 to October 2023, 46 patients with perianal abscess and anal fistula treated at our institution’s Anorectal Surgery Department were enrolled in this prospective randomized controlled study. Patients were randomly allocated into 2 groups: the experimental group (n = 23) received conventional wound care plus a proprietary ointment containing 4.5% bismuth subgallate and 0.7% d-borneol in a Vaseline base, while the control group (n = 23 cases) received conventional wound care alone (comprising daily wound cleansing, dressing changes and traditional Chinese medicine injection). Image J Software was used for collecting the data of wound area, and the wound healing rate and granulation growth rate of the 2 groups were calculated to evaluate the therapeutic effect of the 2 groups.Results:The growth rate of cured granulation in the experimental group was higher than that in the control group at all 3 predetermined observation points, with statistically significant difference (P < .05). Furthermore, the wound healing rate of the experimental group showed significant improvement by day 14 (P < .05).Conclusion:The bismuth subgallate-borneol compound ointment, when used as an adjuvant to standard wound care protocols, demonstrates significant efficacy in treating post-anorectal surgery infectious wounds. Its dual-active component formulation appears to effectively promote both granulation tissue formation and wound healing, potentially through its documented antibacterial properties.

01 Oct 2024·Results in Chemistry

Revolutionizing sensing technologies: Crafting a green, ultra-sensitive bismuth optical sensor via fixation of 5-(2′,4′-dimethyl-phenylazo)-6-hydroxypyrimidine-2,4-dione on PVC membrane

Author: Amin, Alaa S. ; El-Sayed, Refat ; Debbabi, Khaled F. ; Babalghith, Ahmad O. ; El-Bahy, Salah M.

An innovative and exceptionally responsive optical sensing device engineered to selectively identify Bi(III) ions in water-based solutionsThe sensing component, 5-(2′,4′-dimethylphenylazo)-6-hydroxypyrimidine-2,4-dione (DMPAHPD), is incorporated into a plasticized polyvinyl chloride (PVC) membrane.The sensor demonstrates an exceptional selectivity for Bi(III) within a broad dynamic range spanning from 7.5 x 10^-10 to 4.2 x 10^-5 M at pH 2.25.Notably, it achieves lower quantification and detection limits of 7.25 x 10^-10 and 2.15 x 10^-10 M, resp.The optode membrane′s response to Bi(III) proves to be entirely reversible, demonstrating remarkable selectivity for Bi(III) ions over a diverse range of other cations and anions.The sensor exhibits favorable performance characteristics, including good reversibility, a wide dynamic range, a prolonged lifespan, sustained response stability over the long term, and high reproducibility.This visual chem. sensor exhibits potential for real-world usage, offering consistent outcomes when assessing Bi(III) levels in matrixes such as water, soil, plants, biol. and synthetic mixturesImportantly, the sensor′s performance is comparable to corresponding data achieved from inductively coupled plasma at. emission spectroscopy (ICP-AES).

01 Mar 2024·American Journal of Otolaryngology

Effectiveness of bismuth subgallate for preventing bleeding following adenotonsillectomy: A multicentre study

Article

Author: Giacomarra, Vittorio ; Barbi, Egidio ; Fabbris, Cristoforo ; Trombetta, Andrea ; Grasso, Domenico Leonardo ; Zamagni, Giulia ; Dall'Amico, Roberto ; Sanson, Irene ; Orzan, Eva

BACKGROUNDTonsillectomy and adenotonsillectomy are surgical procedures routinely performed worldwide, with various complications, including postoperative bleeding (PTH). Among haemostatic agents, bismuth subgallate (BS) has been employed in the past decades, but its use is controversial in children.OBJECTIVEThis retrospective, multicentre study aims to evaluate the effectiveness and safety of BS in preventing PTH following tonsillectomy and adenotonsillectomy.MATERIALS AND METHODSTwo cohorts of children between 0 and 18 years of age were compared in two different hospitals. The first (active) group of patients included children who underwent tonsillectomy/adenotonsillectomy performed using BS added to gauze swabs, whereas this agent was not administered to the second (control) group. The following variables were analysed: age, gender, degree of tonsillar hyperplasia, length of hospital stay, acute complications (including bleeding and infection), further admissions to the Paediatric Emergency Department (PED), and further hospital admissions in the 30 days postoperatively.RESULTSFour-thousand- seven hundred forty-four children were included in the study, 2598 in the active group and 2146 in the control group. The cases included in the active treatment group displayed a significantly reduced PTH prevalence, 1.4 versus 2.6 % (p < 0.05). No cases of neurological complications or aspiration pneumonia were detected.CONCLUSIONSThis study supports BS as a safe and reliable option for preventing severe PTH following tonsillectomy/adenotonsillectomy.

100 Deals associated with Bismuth subgallate

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Indication	Country/Location	Organization	Date
Diarrhea	Japan	-	01 Jan 1979

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