Last update 15 Sep 2025

S-151128

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
S 151128, S151128
Target
Nav1.7
Action
inhibitors
Mechanism
Nav1.7 inhibitors(Sodium channel protein type IX alpha subunit inhibitors)
Therapeutic Areas
Immune System DiseasesNervous System DiseasesSkin and Musculoskeletal Diseases+ [1]
Active Indication
Osteoarthritis, KneeChronic Pain
Inactive Indication-
Originator Organization
Shionogi & Co., Ltd.Shionogi & Co., Ltd.
Active Organization
Shionogi & Co., Ltd.Shionogi & Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with S-151128
JPRN-jRCT2031230458
/ RecruitingPhase 1
A phase 1b, parallel-group, observer-blind, 2-arm, 2-dose study to investigate the safety and tolerability of intravenous S-151128 compared with placebo in male and female participants aged 40 to 75 with knee osteoarthritis
JPRN-jRCT2031230023
/ Not yet recruitingPhase 1
A phase 1 single-dose study of S-151128 in Japanese healthy adults
100 Clinical Results associated with S-151128
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100 Translational Medicine associated with S-151128
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100 Patents (Medical) associated with S-151128
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100 Deals associated with S-151128
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoarthritis, KneePhase 1
Japan
Shionogi & Co., Ltd.Shionogi & Co., Ltd.
19 Nov 2023
Chronic PainPhase 1
Japan
Shionogi & Co., Ltd.Shionogi & Co., Ltd.
16 Apr 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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