Delving into the Latest Updates on Sporeamicins A with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

50S subunit

Action

inhibitors

Mechanism

50S subunit inhibitors(50S ribosomal subunit inhibitors)

Therapeutic Areas

Infectious Diseases

Active Indication-

Inactive Indication

Bacterial Infections

Originator Organization

Asahi Kasei Corp.

Active Organization-

Inactive Organization

Asahi Kasei Corp.

License Organization-

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC37H63NO12

InChIKeySZZIJYBWFJCYOX-DHWUZCQFSA-N

CAS Registry131418-65-0

The conversion of 6-deoxyerythromycin A (I) to 6-deoxysporeamicin A (II) is described.The antibacterial spectrum of II was similar to those of I, erythromycin, and sporeamicin A, but it had better potency against susceptible streptococci than I.II also had better activity than sporeamicin A against most susceptible organisms and an overall potency similar to that of erythromycin.

01 Jun 1995·BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of the macrolide antibiotic, oxolide

Author: Brian A. Roden ; Sanjay Chemburkar ; Leslie Freiberg ; Yi-Yin Ku ; Richard Pariza

Oxolide (I), an acid-stable macrolide, was synthesized from erythromycin A in 7% overall yield.Key features include two stereoselective reductions with DIBALH and NaBH₃CN and a simple pH dependent separation of the final product from its C-11 epimer.

01 Jan 1992·The Journal of antibioticsQ4 · MEDICINE

Sporeamicin A, a new macrolide antibiotic. I. Taxonomy, fermentation, isolation and characterization.

Q4 · MEDICINE

Article

Author: Kenya Ishizawa ; Satoshi Yaginuma ; Atsuki Morishita ; Mitsuo Hayashi ; Sakae Murofushi ; Naoki Mutoh

Sporeamicin A, a novel antibiotic, was isolated from the culture filtrate of an actinomycete. The producing organism, strain L53-18, was taxonomically assigned as a species of the genus Saccaropolyspora. The antibiotic was extracted with chloroform and was then purified by crystallization. It was obtained as colorless prisms from ethanolic solutions. Sporeamicin A exhibited a strong UV absorption peak at 276 nm. The molecular formula of sporeamicin A was determined to be C37H63NO12.

100 Deals associated with Sporeamicins A

Login to view more data