100 Clinical Results associated with GalNAc-LYTACs
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100 Translational Medicine associated with GalNAc-LYTACs
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100 Patents (Medical) associated with GalNAc-LYTACs
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Literatures (Medical) associated with GalNAc-LYTACs
01 Sep 2021·Nature Chemical Biology
Lysosome-targeting chimeras evolve
Article
Author: Paulk, Joshiawa
A review.LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome.Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.
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