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Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Mechanism-

Therapeutic Areas

NeoplasmsInfectious DiseasesSkin and Musculoskeletal Diseases+ [1]

Active Indication-

Inactive Indication

CarcinomaCryptococcosisKlebsiella Infections+ [3]

Originator Organization

Bristol Myers Squibb Co.

Active Organization-

Inactive Organization

Bristol Myers Squibb Co.

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

Co-culture of the fungus Aspergillus fumigatus with the bacteria Streptomyces peucetius led to the induction of production of formyl xanthocillin analogues. This mixed fermentation yielded two new metabolites, fumiformamide (1) and N,N'-((1Z,3Z)-1,4-bis(4-methoxyphenyl)buta-1,3-diene-2,3-diyl)diformamide (2), together with two known N-formyl derivatives and the xanthocillin analogue BU-4704. The structures were determined by spectroscopic methods and by comparison with literature. Cytotoxic activity of all the analogues was tested on the NCI-60 cell line screen, and compound 2 exhibited significant activity against several cell lines. The analogues did not show antimicrobial activity.

01 Jan 1993·The Journal of AntibioticsQ4 · MEDICINE

BU-4704, a new member of the xanthocillin class.

Q4 · MEDICINE

Article

Author: Noriyuki Ohkusa ; Shinji Murata ; Mltsuaki Tsunakawa ; Yosuke Sawada ; Yukio Narita ; Seikichi Kobaru ; Toshikazu Oki

The mol. structure of the title compound, 4-MeOC₆H₄CH:C(NC)C(NC):CHC₆H₄OMe-4 (I), was determined from NMR data.I strongly inhibits the growth of Gram-pos. and -neg. bacteria and fungi.It demonstrated potent cytotoxic activity against human colon carcinoma and murine melanoma.

100 Deals associated with BU-4704

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Carcinoma	Discovery	US	Bristol Myers Squibb Co.	-
Cryptococcosis	Discovery	US	Bristol Myers Squibb Co.	-
Klebsiella Infections	Discovery	US	Bristol Myers Squibb Co.	-
Melanoma	Discovery	US	Bristol Myers Squibb Co.	-
Staphylococcal Infections	Discovery	US	Bristol Myers Squibb Co.	-
Trichophyton Infection	Discovery	US	Bristol Myers Squibb Co.	-