Last update 10 Jul 2025

BMS-986470

Overview

Basic Info

Drug Type
Degradable Molecular Glue
Synonyms
BMS 986470, BMS986470
Target
CRBN x WIZ x ZBTB7A
Action
modulators, degraders
Mechanism
CRBN modulators(Cereblon modulators), WIZ degraders(WIZ zinc finger degraders), ZBTB7A degraders(zinc finger and BTB domain containing 7A degraders)
Therapeutic Areas
Congenital DisordersHemic and Lymphatic DiseasesOther Diseases
Active Indication
Anemia, Sickle Cell
Inactive Indication-
Originator Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Active Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
RegulationOrphan Drug (United States)
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Related

1
Clinical Trials associated with BMS-986470
NCT06481306
/ RecruitingPhase 1/2
A Phase 1/2a, First-in-human, Randomized, Double-blinded, Placebo-controlled, Dose-finding Study in Healthy Volunteers and Participants With Sickle Cell Disease to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, pH and Food Effect, and Preliminary Efficacy of BMS-986470
100 Clinical Results associated with BMS-986470
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100 Translational Medicine associated with BMS-986470
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100 Patents (Medical) associated with BMS-986470
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100 Deals associated with BMS-986470
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Anemia, Sickle CellPhase 2
United States
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
17 Jul 2024
Anemia, Sickle CellPhase 2
France
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
17 Jul 2024
Anemia, Sickle CellPhase 2
United Kingdom
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
17 Jul 2024
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Clinical Trial

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Approval

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Regulation

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