Last update 09 Apr 2025

BMS-986470

Overview

Basic Info

Drug Type
Degradable Molecular Glue
Synonyms-
Target
CRBN x WIZ x ZBTB7A
Action
modulators, inhibitors
Mechanism
CRBN modulators(Cereblon modulators), WIZ inhibitors(WIZ zinc finger inhibitors), ZBTB7A inhibitors(zinc finger and BTB domain containing 7A inhibitors)
Therapeutic Areas
Congenital DisordersHemic and Lymphatic DiseasesOther Diseases
Active Indication
Anemia, Sickle Cell
Inactive Indication-
Originator Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Active Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with BMS-986470
NCT06481306
/ RecruitingPhase 1/2
A Phase 1/2a, First-in-human, Randomized, Double-blinded, Placebo-controlled, Dose-finding Study in Healthy Volunteers and Participants With Sickle Cell Disease to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, pH and Food Effect, and Preliminary Efficacy of BMS-986470
100 Clinical Results associated with BMS-986470
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100 Translational Medicine associated with BMS-986470
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100 Patents (Medical) associated with BMS-986470
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100 Deals associated with BMS-986470
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Anemia, Sickle CellPhase 2
United States
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
17 Jul 2024
Anemia, Sickle CellPhase 2
France
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
17 Jul 2024
Anemia, Sickle CellPhase 2
United Kingdom
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
17 Jul 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Clinical Trial

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Approval

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Regulation

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