It is a single blind randomized symptom triggered study to assess efficacy and safety of pregablin combined with the symptom triggered treatment for opiate withdrawal syndrome vs. clonidne with the same with the symptom triggered treatment for opiate withdrawal syndrome.

Start Date01 Jan 2014

Sponsor / Collaborator-

100 Clinical Results associated with Phenazepam

100 Translational Medicine associated with Phenazepam

100 Patents (Medical) associated with Phenazepam

307

Literatures (Medical) associated with Phenazepam

15 Nov 2024·Journal of Analytical Toxicology

Deaths involving novel benzodiazepines in Victoria, Australia from 2018 to 2022

Article

Author: Di Rago, Matthew ; Glowacki, Linda ; Crump, Kerryn ; Gerostamoulos, Dimitri ; Joubert, Samantha ; Drummer, Olaf H ; Castle, Jared W

AbstractNovel benzodiazepine (NBz) detections in Victorian coronial cases started early in 2018 and have continued to increase in number and type up to December 2022. The 11 different NBz detections included etizolam (n = 82), flualprazolam (n = 43), clonazolam or 8-aminoclonazolam (n = 30), bromazolam (n = 15), clobromazolam (n = 13), phenazepam (n = 13), flubromazolam (n = 12), flubromazepam (n = 8), desalkylflurazepam (n = 6), diclazepam (n = 2), and estazolam (n = 1). The pattern of detections varied over the 5-year period, with different compounds appearing over different time frames. The most recent NBz to appear were bromazolam, clobromazolam, flubromazepam, and phenazepam, whereas etizolam had been seen regularly in case work since 2018. Of the total 133 deaths, 95 were considered drug-related deaths by forensic pathologists with at least one additional CNS depressant also present capable of contributing to death. All deaths involved other (non-benzodiazepine) CNS active drugs, although many involved multiple NBz, with five or more different benzodiazepines detected in eight cases.

01 Sep 2024·Bulletin of Experimental Biology and Medicine

Comparative Study of the Anxiolytic Activity of Songorine in Elevated Plus Maze Test and by Recording Ultrasonic Vocalizations

Article

Author: Zhdanov, V. V. ; Vsyakikh, O V ; Zhdanov, V V ; Nesterova, Yu V ; Suslov, N I ; Losev, E. A. ; Nesterova, Yu. V. ; Vsyakikh, O. V. ; Povetyeva, T. N. ; Losev, E A ; Zyuz'kov, G N ; Zyuz’kov, G. N. ; Povetyeva, T N ; Suslov, N. I. ; Kul’pin, P. V. ; Kul'pin, P V

It was found that the diterpene alkaloid songorine administered per os to mice at a dose of 25 μg/kg provides a pronounced anxiolytic effect during elevated plus maze testing comparable to the effect of the benzodiazepine anxiolytic phenazepam. Recording of ultrasonic vocalizations of animals revealed an increase in the number of short high-frequency (50 kHz) signals under the action of songorine and the reference drug, which confirms their anti-anxiety properties.

11 Jun 2024·Journal of Analytical Toxicology

Identification of clobromazolam in Australian emergency department intoxications using data-independent high-resolution mass spectrometry and the HighResNPS.com database

Article

Author: Di Rago, Matthew ; Castle, Jared W ; Schumann, Jennifer L ; Gerostamoulos, Dimitri ; Glowacki, Linda L ; Syrjanen, Rebekka ; Greene, Shaun L

AbstractThe proliferation of novel psychoactive substances (NPSs) continues to challenge toxicology laboratories. In particular, the United Nations Office on Drugs and Crime considers designer benzodiazepines to be a current primary threat among all NPSs. Herein, we report detection of a new emerging designer benzodiazepine, clobromazolam, using high-resolution mass spectrometry and untargeted data acquisition in combination with a “suspect screening” method built from the crowd-sourced HighResNPS.com database. Our laboratory first detected clobromazolam in emergency department presenting intoxications included within the Emerging Drugs Network of Australia—Victoria project in the state of Victoria, Australia, from April 2022 to March 2023. Clobromazolam was the most frequent designer benzodiazepine detected in this cohort (100/993 cases, 10%). No patients reported intentional administration of clobromazolam, although over half reported exposure to alprazolam, which was detected in only 7% of cases. Polydrug use was prevalent (98%), with phenazepam (45%), methylamphetamine (71%) and other benzodiazepines (60%) most frequently co-detected. This is the first case series published in the literature concerning clobromazolam in clinical patients. The identification of clobromazolam in patients presenting to emergency departments in Victoria demonstrates how high-resolution mass spectrometry coupled with the HighResNPS.com database can be a valuable tool to assist toxicology laboratories in keeping abreast of emerging psychoactive drug use.

100 Deals associated with Phenazepam

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