Abstract::Derivatives of 1,3,4-oxadiazole are effective in the treatment and cure of a wide range
of diseases in medical chemistry, while industrial development has shown that they can be utilised
as corrosion inhibitors and light-emitting diodes. The researchers discovered several promising
synthetic strategies that created 1,3,4-oxadiazoles in extraordinarily high yields while using environmentally
friendly methods. These compounds can potentially be used in a wide range of lifechanging
applications. Stable isomeric oxadiazole forms of pleconaril, raltegravir, butalamine,
fasiplon, oxolamine, and several other drugs are among the numerous potent and effective pharmaceuticals
that are now on the market. Fasiplon, butalamine, raltegravir, and pleconaril treat
HIV/AIDS patients. This article has attempted to bring attention to the chemistry and pharmacology
of oxadiazole and its derivatives. Oxadiazole derivatives have been used extensively as prospective
therapeutic agents in clinical research, and this has become standard practice. The use of biological
and in-silico models has enabled scientists to identify more synthetic analogues of cancer prevention,
antifungal, and anti-HIV medications. This article provides recent information regarding procedures
for synthesizing 1,3,4-oxadiazoles and their biological actions on the body.