Delving into the Latest Updates on TAN-118 with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms

TAN-118

Target-

Action-

Mechanism-

Therapeutic Areas

Immune System DiseasesDigestive System Disorders

Active Indication

Ulcerative colitis, active moderateUlcerative colitis, active severe

Inactive Indication-

Originator Organization

Shanghai Thederma Pharmaceuticals Co., Ltd.

Active Organization

Shanghai Thederma Pharmaceuticals Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

Login to view timeline

A randomized, double-blind, placebo-controlled Phase IIa exploratory proof-of-concept (PoC) clinical trial to evaluate the safety, tolerability, preliminary efficacy based on the modified Mayo score (mMayo), and pharmacokinetics of TAN-118 tablets in patients with active ulcerative colitis (UC) during a 4-week induction treatment.

Start Date15 May 2026

Sponsor / Collaborator

Sir Run Run Shaw Hospital

[+1]

ChiCTR2600125341

/ Not yet recruitingPhase 2IIT

A randomized, double-blind, placebo-controlled Phase IIa clinical trial to evaluate the safety, tolerability, preliminary efficacy based on the modified Mayo score, and pharmacokinetics/pharmacodynamics of multiple-dose 8-week induction treatment with TAN-118 tablets in patients with moderate to severe active ulcerative colitis.

Start Date15 May 2026

Sponsor / Collaborator

Sir Run Run Shaw Hospital

[+1]

CTR20260695

/ RecruitingPhase 1

评价TAN-118片在成人健康受试者中的单、多次给药的局部药代动力学的I期临床试验

[Translation] A Phase I clinical trial evaluating the local pharmacokinetics of TAN-118 tablets under single and multiple doses in healthy adult subjects.

定量分析单次与多次给药后TAN-118及其主要代谢物在不同结肠段组织中的浓度分布。

[Translation]

Quantitative analysis was conducted on the concentration distribution of TAN-118 and its main metabolites in different colonic tissues after single and multiple administrations.

Start Date07 May 2026

Sponsor / Collaborator

Shanghai Thederma Pharmaceuticals Co., Ltd.

100 Clinical Results associated with TAN-118

Login to view more data

100 Translational Medicine associated with TAN-118

Login to view more data

100 Patents (Medical) associated with TAN-118

Login to view more data

100 Deals associated with TAN-118

Login to view more data

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Ulcerative colitis, active moderate	Phase 2	China	Shanghai Thederma Pharmaceuticals Co., Ltd.	02 Apr 2026
Ulcerative colitis, active severe	Phase 2	China	Shanghai Thederma Pharmaceuticals Co., Ltd.	02 Apr 2026