Last update 05 Dec 2025

CD19-BAFF Targeted CAR T-cells(Yake Biotechnology)

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms-
Target
BAFF x CD19
Action
modulators
Mechanism
BAFF modulators(B-cell-activating factor/B lymphocyte stimulator modulators), CD19 modulators(B-lymphocyte antigen CD19 modulators)
Therapeutic Areas
NeoplasmsImmune System DiseasesInfectious Diseases+ [5]
Active Indication
Diffuse Large B-Cell LymphomaPhiladelphia Chromosome Negative Acute Lymphoblastic LeukemiaNeuromyelitis Optica+ [2]
Inactive Indication-
Originator Organization
Shanghai Yake Biotechnology Co., LtdShanghai Yake Biotechnology Co., Ltd
Active Organization
Shanghai Yake Biotechnology Co., LtdShanghai Yake Biotechnology Co., Ltd
Inactive Organization-
License Organization-
Drug Highest PhaseEarly Phase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with CD19-BAFF Targeted CAR T-cells(Yake Biotechnology)
NCT06346912
/ RecruitingEarly Phase 1IIT
A Study of CD19-BAFF CAR-T Cells Therapy for Patients With Relapsed and/or Refractory B-cell ALL and B-cell NHL
NCT06279923
/ RecruitingEarly Phase 1IIT
Clinical Study of Targeting CD19-BAFF CAR-T Cells in the Treatment of Autoimmune Diseases
100 Clinical Results associated with CD19-BAFF Targeted CAR T-cells(Yake Biotechnology)
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100 Translational Medicine associated with CD19-BAFF Targeted CAR T-cells(Yake Biotechnology)
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100 Patents (Medical) associated with CD19-BAFF Targeted CAR T-cells(Yake Biotechnology)
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100 Deals associated with CD19-BAFF Targeted CAR T-cells(Yake Biotechnology)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diffuse Large B-Cell LymphomaPhase 1
China
Shanghai Yake Biotechnology Co., LtdShanghai Yake Biotechnology Co., Ltd
30 May 2024
Philadelphia Chromosome Negative Acute Lymphoblastic LeukemiaPhase 1
China
Shanghai Yake Biotechnology Co., LtdShanghai Yake Biotechnology Co., Ltd
30 May 2024
Neuromyelitis OpticaPhase 1
China
Shanghai Yake Biotechnology Co., LtdShanghai Yake Biotechnology Co., Ltd
15 Apr 2024
Scleroderma, SystemicPhase 1
China
Shanghai Yake Biotechnology Co., LtdShanghai Yake Biotechnology Co., Ltd
15 Apr 2024
Systemic Lupus ErythematosusPhase 1
China
Shanghai Yake Biotechnology Co., LtdShanghai Yake Biotechnology Co., Ltd
15 Apr 2024
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Clinical Result

Indication
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Clinical Trial

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Approval

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Regulation

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