Lespedeza bicolor Turcz. is a traditional medicinal plant with a wide range of ethnomedicinal values.The main components of L. bicolor essential oil (EO) were β-pinene (15.41%), β-phellandrene (12.43%), and caryophyllene (7.79%).The EO of L. bicolor showed antioxidant activity against ABTS radical and DPPH radical with an IC₅₀ value of 0.69 ± 0.03 mg/mL and 10.44 ± 2.09 mg/mL, resp.The FRAP antioxidant value was 81.96 ± 6.17 μmol/g.The EO had activities against acetylcholinesterase, α-glucosidase, and β-lactamase with IC₅₀ values of 309.30 ± 11.16 μg/mL, 360.47 ± 35.67 μg/mL, and 27.54 ± 1.21 μg/mL, resp.Mol. docking showed Me dehydroabietate docked well with all tested enzymes.Sclareol and (+)-borneol acetate showed the strongest binding affinity to α-glucosidase and β-lactamase, resp.The present study provides a direction for searching enzyme inhibitors for three tested enzymes and shows L. bicolor EO possesses the potential to treat a series of diseases.

01 Jun 2025·Fluid Phase Equilibria

Acidic deep eutectic systems and their capacity to increase drug bioavailability

Author: Duarte, Ana Rita C. ; Fernandes, Claudio C. ; Ferreira, Ines J.

The pharmaceutical industry faces several challenges concerning the bioavailability of novel medications mainly because of their limited permeability and/or solubilityThese are two crucial features that influence how well a medication is absorbed.The biopharmaceutics categorization system is a crucial instrument for the classification of active pharmaceutical ingredients (API) based on their permeability and solubilityIn this work we explored the possibility of deep eutectic systems (DES) to be used as solubility and permeability enhancers of four different drugs supplied by Boeringher Ingelheim.In this investigation, the API′s were dissolved in various DES and their solubility measured in PBS at 37 °C.Our findings suggest that CA: Gly: W (1:1:1) was able to increase the solubility of all four drugs in PBS, as well as their permeability.In summary, BI0001 and BI0002 following pre-solubilization in that system drugs shifted from class III to from class I included, whereas BI0005 still kept its class III classification although having higher solubility and permeability.The encouraging outcomes highlight DES′s potential as a technique to boost drug′s bioavailability.

03 Apr 2025·Aerosol Science and Technology

Aerosol chemistry of oxygenated terpenes in simple and complex chemical systems

Author: Gu, Shan ; Krechmer, Jordan ; Faiola, Celia L. ; Khalaj, Farzaneh ; Mehra, Archit ; Williams, Leah R. ; Lambe, Andrew ; Perraud, Veronique

Terrestrial vegetation emits complex mixtures of highly reactive biogenic volatile organic compounds (BVOCs) that contribute to secondary organic aerosol (SOA) formation.The aerosol chem. of many BVOCs remains unexplored.Oxygenated monoterpenes are one class of BVOCs that comprise a large proportion of woody shrub emission profiles and can also be induced after stress exposure.In this work, SOA was generated from the photooxidation of oxygenated monoterpenes in an oxidation flow reactor and compared to SOA generated from a reference cyclic terpene-α-pinene.The oxygenated terpenes used as SOA precursors included camphor (C₁₀H₁₆O), borneol (C₁₀H₁₈O), 1,8-cineole (C₁₀H₁₈O), and bornyl acetate (C₁₂H₂₀O₂).Results show that SOA mass yields from oxygenated terpenes were usually greater than or equal to α-pinene except for bornyl acetate, which had the lowest yields.SOA composition measured offline with liquid chromatog. high resolution mass spectrometry (UHPLC-ESI-HRMS) was used to compare the different SOA types.Addnl., the composition of SOA generated from emissions of two coastal sage shrubs, with emissions dominated by oxygenated terpenes, was compared with SOA formed from single component standards using aerosol mass spectrometry.The composition of 1,8-cineole SOA was most dissimilar from the other types of SOA.Addnl., SOA generated from real plant emissions of two different species was more similar in composition to one another than to the SOA generated from the individual components, suggesting non-linearity of the chem. of BVOC mixturesThese results highlight the importance of biogenic SOA studies using complex mixtures that are more representative of real plant emissions.

100 Deals associated with Borneol

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Indication	Country/Location	Organization	Date
Pain	China	Zhuzhou Sonbon Pharmaceutical Co., Ltd.	01 Jan 1982

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