Last update 08 Nov 2024

Benzonatate

Overview

Basic Info

SummaryTESSALON® (Benzonatate) is an FDA-approved non-narcotic oral antitussive medication manufactured by Pfizer Inc. It was first approved in the United States in 1958 for the symptomatic relief of cough. TESSALON acts as a sodium channel blocker, anesthetizing the stretch receptors in the respiratory passages, lungs, and pleura to dampen their activity and reduce the cough reflex. Its effect starts within 15-20 minutes and can last between 3-8 hours. TESSALON has no inhibitory effect on the respiratory center when used as recommended. The active ingredient, 2, 5, 8, 11, 14, 17, 20, 23, 26-nonaoxaoctacosan-28-yl p-(butylamino) benzoate, has a molecular weight of 603.7. TESSALON is solely indicated for the relief of cough, but it has no known potential for abuse or addiction, unlike narcotic antitussives.
Drug Type
Small molecule drug
Synonyms
2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl p-(butylamino)benzoate, 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate, 3,6,9,12,15,18,21,24,27-nonaoxaoctacosyl 4-butylaminobenzoate
+ [8]
Target
Mechanism
SCNA blockers(Sodium channel alpha subunit blockers)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (10 Feb 1958),
Regulation-
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Structure

Molecular FormulaC30H53NO11
InChIKeyMAFMQEKGGFWBAB-UHFFFAOYSA-N
CAS Registry104-31-4

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Cough
US
10 Feb 1958
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dry coughPhase 3
IN
26 Jan 2011
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Clinical Result

Indication
Phase
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Regulation

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