Delving into the Latest Updates on Lysozyme with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms-

Target

Peptidoglycan

Action

inhibitors

Mechanism

Peptidoglycan inhibitors, Cell wall inhibitors

Therapeutic Areas

Infectious DiseasesEye Diseases

Active Indication

BlepharitisConjunctivitisCorneal Ulcer+ [1]

Inactive Indication-

Originator Organization

Shenyang Xingqi Pharmaceutical Co., Ltd.

Active Organization

Shenyang Xingqi Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

China (03 Apr 2019),

BlepharitisConjunctivitisCorneal Ulcer+ [1]

Regulation-

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Structure/Sequence

Sequence Code 1493357

Source: *****

The objective of this study was to design and characterize novel biocomposites based on modified cellulose/alginate oligosaccharides loaded with hen egg lysozyme (CLm/AOS/Lyz) as a potential alternative to combat bacterial proliferation. An antimicrobial enzyme, lysozyme, was immobilized within polymeric matrices to enhance its bactericidal capacity and stability. The biocomposites synthesized at pH levels 3, 5, and 8 (CLm/AOS/Lyz₃, CLm/AOS/Lyz₅, and CLm/AOS/Lyz₈, respectively) were analyzed using Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), and energy-dispersive X-ray spectroscopy (EDS). Results demonstrated successful lysozyme conjugation to the biocomposite without altering its secondary structure or stability. The biocomposites exhibited irregular morphologies and strong adhesion between CLm/AOS and Lyz, with CLm/AOS/Lyz5 showing the highest nitrogen composition and protein content (2086.43 ± 100.90 µg of bovine serum albumin equivalents). Antibacterial assays revealed significant log reductions in viable E. faecalis cells for CLm/AOS/Lyz₃ and CLm/AOS/Lyz₅ (5.72 ± 0.17 and 5.78 ± 0.24 respectively), concerning the blank (8.04 ± 0.07), even comparable to free lysozyme (5.85 ± 0.35). However, no reduction in viable cell counts was observed for Gram-negative bacteria. This work highlights the potential of lysozyme-loaded cellulose-alginate biocomposites as novel antibacterial agents for effective applications in pharmaceutical and food technology fields.

01 May 2025·Food Chemistry

Insight into the binding mechanism of rutin and lysozyme: Based on spectroscopy and molecular simulation technology

Article

Author: Ding, Yue ; Chen, Hui ; Liu, Lili ; Cheng, Weiwei ; Xiao, Feng ; Yang, Le

Lysozyme (LYZ) is an excellent natural food preservative and can also be used as a bioactive carrier loading small molecules to enhance its stability and antioxidant properties. This research explored the intricate mechanism of interaction between LYZ and rutin. Multiple spectroscopic techniques was used first to confirm that rutin caused a fluorescence burst in LYZ. LYZ amino acid microenvironment was altered. The main driving forces driving the formation of the complex between rutin and LYZ were hydrogen bonding and van der Waals forces. In addition, the incorporation of rutin improved the overall stability and oxidation resistance of the complexes. The results of molecular docking and molecular dynamics simulation further show that rutin and LYZ are stably bound by hydrogen bonds and other interactions. The investigation contributed precious information for the development of novel natural preservatives and the design of advanced small molecular carriers.

01 May 2025·International Journal of Biological Macromolecules

Mechanistic insight into association of lysozyme, serum albumin, and insulin with aloin: Thermodynamic and conformational analysis

Article

Author: Jain, Anu ; Kishore, Nand

Lysozyme, serum albumin, and insulin carry out essential functions in the living systems. The properties and functions of these proteins may be positively impacted in association with Aloe vera, which is known to have usefulness as dietary supplement and clinical conditions. In this work, the conformational changes in these proteins have been analysed as a result of interaction with aloin, which has a long history of use in traditional health management. A combination of circular dichroism spectroscopy, fluorescence spectroscopy, and isothermal titration calorimetry have been used in analysing the associated thermodynamic signatures and structural changes. It is observed that lysozyme, and bovine serum albumin showed weak binding behaviour with aloin at molar ratio of (1:1), which is found to be entropically driven at first binding site while enthalpically driven at second binding site. Similarly for insulin also, the interaction of aloin increased with increase in its concentration and the binding of ligand at first and second site is entropically and enthalpically driven, respectively. These three proteins offer hydrophobic and hydrophilic functionalities for establishing intermolecular interactions with aloin. Differential scanning calorimetry and circular dichroism spectroscopy have provided mechanistic details on tertiary structural changes in these proteins as a result of interactions. The results offer valuable insights into molecular mechanism of conformational changes in these proteins and hence their properties in association with aloin, thereby, having biological implications related to health and food industry.

100 Deals associated with Lysozyme

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Lysozyme	-	DB13260

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Blepharitis	China	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019
Conjunctivitis	China	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019
Corneal Ulcer	China	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019
Dacryocystitis	China	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2010	Not Applicable	-	-	EOBO alone	ndovlugjff(xgahmrjtkq) = nbbitozvit nvzzvanbtg (ljcaosjmmc ) View more	-	01 Apr 2010
				Di-Block Copolymer, Poly(oxyethylene)-Poly(oxybutylene)lysozymelymer, Poly(oxyethylene)-Poly(oxybutylene) (EOBO-lysozyme mixture)	ndovlugjff(xgahmrjtkq) = bcuvjneidd nvzzvanbtg (ljcaosjmmc ) View more