Delving into the Latest Updates on Lysozyme with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms-

Target

Peptidoglycan

Mechanism

Peptidoglycan inhibitors, Cell wall inhibitors

Therapeutic Areas

Infectious DiseasesEye Diseases

Active Indication

BlepharitisConjunctivitisCorneal Ulcer+ [1]

Inactive Indication-

Originator Organization

Shenyang Xingqi Pharmaceutical Co., Ltd.

Active Organization

Shenyang Xingqi Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (03 Apr 2019),

BlepharitisConjunctivitisCorneal Ulcer+ [1]

Regulation-

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Gene Sequence

Sequence Code 1493357

Source: *****

OBJECTIVEUltrastructural analyses showed that during erosion under oral cavity conditions, dentin is infiltrated by a substrate morphologically similar to salivary proteins. This in-situ study aimed to investigate the presence of salivary proteins in demineralized dentin.METHODSBovine dentin specimens were attached to individual maxillary splints (n = 1 per subject and condition) and worn intraorally by four subjects for 1 min. During intraoral exposure, the subjects rinsed with 10 ml of either sterile water or 1% citric acid. Additional specimens were eroded in-vitro as controls (n = 2). The specimens were then fixed, embedded in acrylic resin, and ultrathin sections were prepared. The salivary protein lysozyme was labelled with immunogold staining and examined using transmission electron microscopy.RESULTSLysozyme was absent in the in-vitro controls but was detected on the dentin surface after rinsing with water, indicating its role in the initial pellicle formation on dentin. After rinsing with citric acid, lysozyme infiltrated deeper layers of the dentin.CONCLUSIONSThese findings support the initial morphological observations that lysozyme, representing other salivary proteins, is deposited in demineralized dentin during erosion with citric acid.CLINICAL SIGNIFICANCEInfiltration of salivary proteins into dentin during erosive processes can be a factor to consider in remineralization approaches under oral cavity conditions.

01 Jan 2025·Journal of Colloid and Interface Science

Natural agents derived Pickering emulsion enabled by silica nanoparticles with enhanced antibacterial activity against drug-resistant bacteria

Article

Author: Wang, Meiyan ; Zhang, Ye ; Zhang, Jun ; Liu, Chao ; Yu, Chengzhong ; Feng, Jiayou ; Yao, Yining ; Wang, Yue ; Ao, Niqi

The emergence of antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) has become a global health challenge due to the overuse of antibiotics. Natural substances including enzymes and essential oils have shown great potential as alternative treatment options. However, the combinational use of these natural agents remains challenging due to the denaturation of enzymes upon direct contact with oil. In this study, we report the design of a Pickering emulsion containing two natural antibacterial agents, lysozyme and tea tree oil, stabilized by fractal silica nanoparticles. In this design, the enzyme activity is kept and the volatility problem of tea tree oil is mitigated. Due to synergistic bacterial cell wall digestion and membrane disruption functions, potent bactericidal efficacy in vitro against drug-resistant bacteria is achieved. The therapeutic potential is further demonstrated in a wound healing model with drug-resistant bacteria infection, better than a synthetic antibiotic, Ampicillin. This study opens new avenues for the development of natural product-based antimicrobial treatments with promising application potential.

01 Jan 2025·Journal of Environmental Sciences

Effect of lysozyme combined with hydrothermal pretreatment on excess sludge and anaerobic digestion

Article

Author: Cao, Xiuqin ; Liu, Chaolei ; Li, Songyue

Anaerobic digestion (AD) is widely employed for sludge stabilization and waste reduction. However, the slow hydrolysis process hinders methane production and leads to prolonged sludge issues. In this study, an efficient and eco-friendly lysozyme pre-treatment method was utilized to address these challenges. By optimizing lysozyme dosage, hydrolysis and cell lysis were maximized. Furthermore, lysozyme combined with hydrothermal pretreatment enhanced overall efficiency. Results indicate that: (1) When lysozyme dosage reached 90 mg/g TS after 240 min of pretreatment, SCOD, soluble polysaccharides, and protein content reached their maxima at 855.00, 44.09, and 204.86 mg/L, respectively. This represented an increase of 85.87%, 365.58%, and 259.21% compared to the untreated sludge. Three-dimensional fluorescence spectroscopy revealed the highest fluorescence intensity in the IV region (soluble microbial product), promoting microbial metabolic activity. (2) Lysozyme combined with hydrothermal pretreatment significantly increased SCOD, soluble proteins, and polysaccharide release from sludge, reducing SCOD release time. Orthogonal experiments identified Group 3 as the most effective for SCOD and soluble polysaccharide release, while Group 9 released the most soluble proteins. The significance order of factors influencing SCOD, soluble proteins, and polysaccharide release is hydrothermal temperature > hydrothermal time > enzymatic digestion time.(3) The lysozyme-assisted hydrothermal pretreatment group exhibited the fastest release and the highest SCOD concentration of 8,135.00 mg/L during anaerobic digestion. Maximum SCOD consumption and cumulative gas production increased by 95.89% and 130.58%, respectively, compared to the control group, allowing gas production to conclude 3 days earlier.

100 Deals associated with Lysozyme

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Lysozyme	-	DB13260

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Blepharitis	CN	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019
Conjunctivitis	CN	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019
Corneal Ulcer	CN	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019
Dacryocystitis	CN	Shenyang Xingqi Pharmaceutical Co., Ltd.	03 Apr 2019