Last update 17 Apr 2025

CLL-442

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CLL 442, CLL442
Target
PI3Kα x mTOR
Action
inhibitors
Mechanism
PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Cutaneous Squamous Cell Carcinoma
Originator Organization
Novartis Pharma AG
Active Organization-
Inactive Organization
Novartis Pharmaceuticals Corp.Novartis Pharmaceuticals Corp.
Drug Highest PhasePendingPhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with CLL-442
EUCTR2017-003495-31-BE
/ Not yet recruitingPhase 1/2
A randomized, Investigator-and patient-blind, placebo-controlled, parallel group first in human and proof of concept study to evaluate the safety, tolerability, and efficacy of CLL442 in patients with Cutaneous Squamous Cell Carcinoma in situ (SCCis) - Not applicable
100 Clinical Results associated with CLL-442
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100 Translational Medicine associated with CLL-442
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100 Patents (Medical) associated with CLL-442
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100 Deals associated with CLL-442
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cutaneous Squamous Cell CarcinomaPhase 2
United States
Novartis Pharmaceuticals Corp.Novartis Pharmaceuticals Corp.
14 Dec 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Clinical Trial

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Approval

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Regulation

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