Delving into the Latest Updates on Resokine(aTyr Pharma, Inc.) with Synapse

Overview

Basic Info

Drug Type

Enzyme

Synonyms

Histidyl-tRNA synthetase, Resected-tRNA synthetase, Resokine

+ [6]

Target

Jo-1

Action

inhibitors

Mechanism

Jo-1 inhibitors(Jo-1 autoantibody inhibitors)

Therapeutic Areas

Immune System DiseasesDigestive System Disorders

Active Indication-

Inactive Indication

Immune System DiseasesInflammatory Bowel Diseases

Originator Organization

aTyr Pharma, Inc.

Active Organization-

Inactive Organization

aTyr Pharma, Inc.

License Organization-

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

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Facioscapulohumeral Muscular Dystrophy (FSHD) is in the top three list of all dystrophies with an approximate 1:8000 incidence. It is not a life-threatening disease; however, the progression of the disease extends over being wheelchair bound. Despite some drug trials continuing, including DUX4 inhibition, TGF-ß inhibition and resokine which promote healthier muscle, there is not an applicable treatment option for FSHD today. Still, there is a need for new agents to heal, stop or at least slow down muscle wasting. Current FSHD studies involving nutraceuticals as vitamin C, vitamin E, coenzyme Q10, zinc, selenium, and phytochemicals as curcumin or genistein, daidzein flavonoids provide promising treatment strategies. In this review, we present the clinical and molecular nature of FSHD and focus on nutraceuticals and phytochemicals that may alleviate FSHD. In the light of the association of impaired pathophysiological FSHD pathways with nutraceuticals and phytochemicals according to the literature, we present both studied and novel approaches that can contribute to FSHD treatment.

100 Deals associated with Resokine(aTyr Pharma, Inc.)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Immune System Diseases	Phase 1	European Union	aTyr Pharma, Inc.	-
Inflammatory Bowel Diseases	Phase 1	United States	aTyr Pharma, Inc.	-

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Clinical Result

Indication

Phase

Evaluation

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

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