Last update 12 Dec 2024

Encequidar mesylate/Topotecan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Encequidar/topotecan, Oratopo, topotecan + encequidar
+ [3]
Target
P-gp x TOP1
Mechanism
P-gp inhibitors(P-glycoprotein 1 inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Advanced cancerAdvanced Malignant Solid Neoplasm
Originator Organization
Hanmi Pharmaceutical Co., Ltd.Hanmi Pharmaceutical Co., Ltd.
Active Organization-
Inactive Organization
Athenex, Inc.Athenex, Inc.
Drug Highest PhasePendingPhase 1
First Approval Date-
Regulation-
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Structure

Molecular FormulaC23H24ClN3O5
InChIKeyDGHHQBMTXTWTJV-BQAIUKQQSA-N
CAS Registry119413-54-6
View All Structures (2)

Related

3
Clinical Trials associated with Encequidar mesylate/Topotecan
ACTRN12618000798268 / CompletedPhase 1
An Open-Label, Non-Randomized, Fixed-Sequence Study in Healthy Volunteers to Evaluate the Effect of HM30181A on the Pharmacokinetics of Digoxin
ACTRN12618000791235 / CompletedPhase 1
An Open-Label, Non-Randomized, Fixed Sequence Study in Healthy Volunteers to Evaluate the Effect of HM30181A on the Pharmacokinetics of Dabigatran
NCT03987685 / CompletedPhase 1
A Dose Regimen-Finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Activity of Oral Topotecan With HM30181A Monotherapy in Patients With Advanced Malignancies
100 Clinical Results associated with Encequidar mesylate/Topotecan
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100 Translational Medicine associated with Encequidar mesylate/Topotecan
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100 Patents (Medical) associated with Encequidar mesylate/Topotecan
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100 Deals associated with Encequidar mesylate/Topotecan
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced cancerPhase 1
US
Athenex, Inc.Athenex, Inc.
19 Jul 2018
Advanced cancerPhase 1
GB
Athenex, Inc.Athenex, Inc.
19 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
US
Athenex, Inc.Athenex, Inc.
19 Jul 2018
Advanced Malignant Solid NeoplasmPhase 1
GB
Athenex, Inc.Athenex, Inc.
19 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Approval

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Regulation

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