Delving into the Latest Updates on Talinexomer with Synapse

Overview

Basic Info

Drug Type

Polymer

Synonyms

CLP, HCLP, Talinexomer (USAN/INN)

+ [3]

Target

NKCC2

Action

inhibitors

Mechanism

NKCC2 inhibitors(Sodium-(potassium)-chloride cotransporter 2 inhibitors)

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Heart Failure

Originator Organization

Sorbent Therapeutics, Inc.

Active Organization-

Inactive Organization

Sorbent Therapeutics, Inc.

License Organization-

Drug Highest PhasePendingPhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC18H24O8

InChIKeyKXLBZYRJOGUGLR-UHFFFAOYSA-N

CAS Registry51838-34-7

The leaves of Hemerocallis citrina Baroni ( H. citrina Baroni) are a promising source of bioactive polysaccharides (HCLP). However, the presence of abundant pigments in crude HCLP complicates subsequent purification and analysis, making an effective decolorization step essential. A model of decolorization conditions of HCLP was established using single factor and response surface methodology (RSM), and the optimal decolorization conditions were obtained. Subsequently, the HCLP‐0.1 was successfully isolated via DEAE‐52 cellulose column. Structural characterization revealed that HCLP‐0.1 has a molecular weight ( Mw ) of 8317.64 Da, composed of Man, GlcN, Rha, GlcA, GalA, Glc, Gal, Xyl, and Ara. Furthermore, HCLP‐0.1 was characterized by α‐ and β‐pyranose configurations, crystallinity, and an irregular triple‐helical structure. Thermal analysis demonstrated excellent thermal stability. Antioxidant assays revealed that HCLP‐0.1 possesses significant concentration‐dependent (0.1–2.0 mg/mL) scavenging capacity against ABTS, hydroxyl, and DPPH radicals. These results support the potential of HCLP as a natural antioxidant, providing a solid basis for its future application in functional foods or pharmaceuticals.

01 Nov 2025·EUROPEAN JOURNAL OF PHARMACOLOGY

The ameliorative effect of inhibiting transient receptor potential ankyrin 1 on sepsis-induced kidney injury via the toll-like receptor 4/nuclear factor-kappa B pathway

Author: Bircan, Burak ; Tekin, Suat ; Çakır, Murat ; Şekerci, Güldeniz ; Aydın, Ali ; Fırat, Semanur

BACKGROUND:

Kidneys are among the organs most affected by sepsis caused by the host's uncontrolled immune response to infection. Transient receptor potential ankyrin 1 (TRPA1) channels have been shown to be associated with renal damage. TRPA1 channels also have a role in regulating intracellular Ca²⁺ levels, cytokine production, and immune response control. In this study, the effects of TRPA1 agonist ASP7663 and antagonist HC-030031 on renal injury in an experimental sepsis model were examined.

MATERIALS AND METHODS:

Rats underwent cecal ligation and perforation (CLP) to serve as an experimental sepsis model. One of the two treatment groups received a TRPA1 agonist ASP7663, while the other received a TRPA1 antagonist HC030031. Serum levels of BUN, creatinine (Cre), TNF-α, IL-1β, IL-18, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) were measured. Histopathological examination of kidney tissue was performed. Immunohistochemical analysis of Toll-like receptor 4 (TLR4), NF-κB, phosphorylated NF-κB, IκB-α, phosphorylated IκB-α, TNF-α, IL-1β, IL-6, caspase-3, and caspase-8 levels was conducted in kidney tissue.

RESULTS:

CLP administration raised serum levels of BUN, Cre, TNF-α, IL-1β, IL-18, NGAL, and KIM-1 (P < 0.05). It also caused histopathological damage to kidney tissue. Additionally, CLP increased levels of TLR4, phosphorylated NF-κB, phosphorylated IκB-α, TNF-α, IL-1β, IL-6, caspase-3, and caspase-8 in kidney tissue (P < 0.05). The TRPA1 antagonist HC-030031 reversed all pathological changes in serum and kidney tissue caused by CLP.

CONCLUSION:

TRPA1 antagonist HC-030031 showed a protective effect in an experimental sepsis model by reducing kidney damage through its anti-inflammatory and anti-apoptotic effects.

01 Oct 2025·JOURNAL OF DENTISTRY

Reduction of the erosive potential of a soft drink with polymers and calcium

Article

Author: Nogueira, Fernando Neves ; Borges, Alessandra Bühler ; Sakae, Letícia Oba ; Scaramucci, Taís ; Aoki, Idalina Vieira ; Kairalla, Cláudia Allegrini ; Pessan, Juliano Pelim ; Muniz, Milena Rodrigues

OBJECTIVES:

To evaluate the erosive potential of a soft drink modified with film-forming polymers and calcium on bovine enamel and dentin.

METHODS:

Sprite Zero Sugar was modified with linear sodium polyphosphate (LPP-10 g/L) and sodium trimetaphosphate (TMP-10 g/L), individually or combined with calcium lactate pentahydrate (CLP-4.35 g/L). Enamel and dentin specimens were randomly assigned into six groups (n = 10/substrate): 1. C- (negative control-no modification); 2. LPP; 3. TMP; 4. LPP+CLP; 5. TMP+CLP; 6. C+ (positive control-CLP). The specimens underwent an erosion-remineralization cycling. Surface loss (SL, in μm) was measured with an optical profilometer. Color and viscosity of the drinks were analyzed. Data were statistically analyzed (α=0.05).

RESULTS:

For enamel and dentin, LPP significantly reduced the erosive effect of the drink compared to C- (p < 0.001 for both), with reductions of approximately 53 % and 41 %, respectively. TMP showed no significant difference from C- for both substrates. C+ reduced SL by 87 % in enamel and 38 % in dentin when compared to C- (p < 0.001). When CLP was combined with the polymers, in enamel, a 97 % reduction in SL for LPP+CLP and TMP+CLP was observed. In dentin, reductions of 56 % and 48 % were observed for LPP+CLP and TMP+CLP. No significant differences were observed between the groups and the C- regarding color and viscosity (p > 0.05).

CONCLUSIONS:

All solutions containing calcium lactate (CLP) were effective in reducing the erosive potential of the original soft drink. The combinations of CLP with LPP or TMP significantly enhanced protection, especially for dentin. Notably, LPP alone was effective in minimizing erosion of both enamel and dentin.

CLINICAL RELEVANCE:

Reducing the erosion potential of soft drinks may benefit non-collaborative individuals with high risk for erosive tooth wear.

100 Deals associated with Talinexomer

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External Link

KEGG	Wiki	ATC	Drug Bank
D10992	-	-	-

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Heart Failure	Phase 2	United States	Sorbent Therapeutics, Inc.	01 Apr 2011
Heart Failure	Phase 2	Armenia	Sorbent Therapeutics, Inc.	01 Apr 2011
Heart Failure	Phase 2	Moldova	Sorbent Therapeutics, Inc.	01 Apr 2011