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Last update 08 May 2025

Alprenolol Hydrochloride

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol, 1-(2-Allylphenoxy)-3-isopropylamino-2-propanol, 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol

+ [10]

Target

β-adrenoceptors

Action

antagonists

Mechanism

β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)

Therapeutic Areas

Nervous System DiseasesCardiovascular DiseasesOther Diseases

Active Indication

Angina PectorisArrhythmias, CardiacHypertension

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC15H23NO2

InChIKeyPAZJSJFMUHDSTF-UHFFFAOYSA-N

CAS Registry13655-52-2

View All Structures (2)

100 Clinical Results associated with Alprenolol Hydrochloride

100 Translational Medicine associated with Alprenolol Hydrochloride

100 Patents (Medical) associated with Alprenolol Hydrochloride

2,946

Literatures (Medical) associated with Alprenolol Hydrochloride

08 Apr 2025·Analytical Chemistry

Capillary Zone Electrophoresis-Mass Spectrometry of Intact G Protein-Coupled Receptors Enables Proteoform Profiling

Article

Author: Jooß, Kevin ; Kelleher, Neil L. ; Melani, Rafael D. ; Ives, Ashley N. ; Fellers, Ryan T. ; Janetzko, John

G protein-coupled receptors (GPCRs) are the largest class of integral membrane receptors and responsible for transmitting diverse signals in response to extracellular stimuli. Post-translational modifications serve to dictate the subcellular trafficking and function of a GPCR across space and time. Despite significant interest in mapping the diversity of GPCR modification states (proteoforms), technical challenges have hindered this characterization. While advancements in membrane mimetics and mass spectrometry instrumentation have improved analysis, current workflows require large amounts of homogeneous protein, limiting the study of many GPCRs from mammalian sources. Here, we present capillary zone electrophoresis (CZE) as a separation technique for characterizing proteoforms of both intact and partially digested GPCRs. This method allowed for the characterization of multiple proteoforms of both the β2-adrenergic receptor and metabotropic glutamate receptor 2 using low sample volumes and without buffer optimization. Notably, in the case of smaller phosphorylated analytes, CZE can readily separate positional phosphorylation isomers and provide superior fragmentation coverage to conventional reversed phase-liquid chromatography.

01 Apr 2025·Journal of Pharmaceutical Sciences

Optimization of HPLC method for determination of Abraham solvation parameters of pharmaceuticals

Article

Author: Knašienė, Birutė ; Sadaunykas, Audrius ; Sazonovas, Andrius ; Balčiūnas, Simonas ; Naujalis, Evaldas ; Lanevskij, Kiril

Abraham solvation equation (Absolv) is a popular and well-established approach for modeling solute partitioning between phases of different polarity, which finds its applications in both organic chemistry and biomedical fields. Parameters constituting this equation are good quantitative descriptors of solute hydrogen bonding potential that are useful for QSAR modeling of more complex chemical and biological phenomena. Numerous studies dealing with fast determination of Abraham descriptors using HPLC can be found in the literature, but these mostly focus on small un-ionizable industrial and environmental chemicals, whereas experimental data for pharmaceutical molecules are clearly lacking. In the current study we build upon a previously published chromatographic approach, aiming to adapt the method to ionizable drug-like compounds, and optimize it by reducing the number of required HPLC columns. The analysis involves determination of the overall H-bond acidity (A), H-bond basicity (B) and polarity/polarizability (S) descriptors for 62 pharmaceutical molecules with previously unpublished parameter values.

11 Mar 2025·Analytical Chemistry

Electromembrane Extraction Provides Unprecedented Selectivity for Drugs in Cell Culture Media Used in Organoid and Organ-on-Chip Systems

Article

Author: Krauss, Stefan ; Ro̷berg-Larsen, Hanne ; Skottvoll, Fro̷ydis Sved ; Kogler, Stian ; Hrušková, Helena ; Hansen, Frederik André ; Aizenshtadt, Aleksandra ; Rise, Frode ; Wilson, Steven Ray

The use of organoids and organ-on-chip technologies as nonanimal methodologies in drug discovery and personalized medicine is rapidly expanding. However, the complexity and small volumes of organoid culture samples present significant analytical challenges, e.g., in drug analysis using liquid chromatography-mass spectrometry (LC-MS). Essentially an electrophoresis across an oil membrane, electromembrane extraction (EME) offers a promising approach for measuring drugs, as it is, for example, compatible with small samples such as organoid and organ-on-chip formats. Given the potential of the technology, there is a need to assess the extraction purity of EME extracts to ensure EME's compatibility with high-throughput, downstream analysis. This study evaluates the effectiveness of EME for sample cleanup in various common cell culture media used for organoids and organs-on-chips. The media were spiked with 90 small-molecule drugs. Using gel electrophoresis (sodium dodecyl sulfate polyacrylamide gel electrophoresis), high-resolution nuclear magnetic resonance spectroscopy, and LC-MS, we demonstrate that EME provides exhaustive removal of unwanted medium components (proteins, polar molecules, and apolar/neutral molecules) while selectively extracting the spiked small-molecule drugs. The approach was demonstrated with human stem-cell-derived liver organoids, allowing simple detection and monitoring of telltale cytochrome P450 metabolism. Taken together, our observations highlight an unprecedented ability of EME to provide sample cleanup for drug analysis in matrixes compatible with organoids and organ-on-chip technology.

100 Deals associated with Alprenolol Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D01182	Alprenolol Hydrochloride	C07AA01	DB00866

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Angina Pectoris	-	-	-
Arrhythmias, Cardiac	-	-	-
Hypertension	-	-	-

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