Pinocembrin

Medicinal plants exhibit rich chemical diversity and therapeutic potential, accounting for their broad applications in traditional medicine and the growing number of studies documented in literature. Among the most used species, Lippia spp. are aromatic plants of notable therapeutic interest, with L. alba and L. origanoides predominantly found in the Cerrado and Caatinga regions of Brazil. Despite their traditional use, studies focusing on the hydroalcoholic fractions of these species remain limited yet are crucial for understanding their full phytochemical profiles. This work aims to present an integrative review of the phytochemistry of the leaves of L. alba and L. origanoides , along with a brief overview of their reported bioactivities. The databases used for the literature survey were ScienceDirect, PubMed, and SciELO. A total of 37 articles about the nonvolatile fraction and 65 about the volatile fraction were selected after screening. For L. alba , verbascoside is the primary marker described, whereas for L. origanoides , naringenin and eriodictyol are predominant. The presence of pinocembrin has also been reported in extracts of L. origanoides . Antimicrobial, antioxidant, anxiolytic, and cardiovascular‐related activities have been documented in the literature for these species extracts and essential oils. Given the relative scarcity of studies on their hydroalcoholic profiles compared to volatile compounds, this review highlights the potential of Lippia spp. to contribute to scientific advancement and the development of new natural products.