Last update 08 May 2025

JWG-148

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms-
Target
ABL2 x EPHB2 x SIK2 x TYK2
Action
antagonists, inhibitors
Mechanism
ABL2 antagonists(ABL proto-oncogene 2, non-receptor tyrosine kinase antagonists), EPHB2 antagonists(EPH receptor B2 antagonists), SIK2 inhibitors(Serine/threonine-protein kinase SIK2 inhibitors)
+ [1]
Therapeutic Areas-
Active Indication-
Inactive Indication-
Originator Organization
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.Harvard Medical SchoolHarvard Medical School
Active Organization-
Inactive Organization
Harvard Medical SchoolHarvard Medical SchoolDana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.
License Organization-
Drug Highest PhasePendingDiscovery
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC47H55N9O5S
InChIKeyKEGVGSFRDCGPAX-INBBZAOVSA-N
CAS Registry2769850-28-2

Related

100 Clinical Results associated with JWG-148
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100 Translational Medicine associated with JWG-148
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100 Patents (Medical) associated with JWG-148
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1
Literatures (Medical) associated with JWG-148
01 Dec 2020CellQ1 · BIOLOGY
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development
Q1 · BIOLOGY
100 Deals associated with JWG-148
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R&D Status

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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Approval

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Regulation

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