Delving into the Latest Updates on AL-05712 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Action-

Mechanism-

Therapeutic Areas

Eye Diseases

Active Indication-

Inactive Indication

Eye Diseases

Originator Organization

Alcon Laboratories, Inc.

Active Organization-

Inactive Organization

Alcon AG

License Organization-

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC10H16N2O4S2

InChIKeyXGBGHXUHZUXRCM-UHFFFAOYSA-N

CAS Registry131760-66-2

It has been previously shown that during the aging process, the human eye lens accumulates protein-glutathione mixed disulfides (PSSG) and that the reduced glutathione (GSH) level drops. These changes become even more pronounced during cataractogenesis. In this report, the ability of AL-05712 and AL-05741 to lower PSSG and elevate GSH in three separate model systems was evaluated. AL-05741 was able to decrease PSSG in the cell-free system by over 30% at a concentration of 0.1 mM. AL-05712, the ester form of AL-05741, decreased mixed disulfides by about 8% in the same system in the absence of any cellular esterases. Both compounds could partially inhibit the loss of GSH seen in the H2O2 control in cultured rat lenses and in addition, the accumulation of PSSG was substantially decreased. Human lenses incubated in AL-05712 showed a significant elevation of cortical GSH and a decrease in PSSG in three of four sets of cultured human lenses.

01 Mar 1991·The Journal of Organic Chemistry

A reagent for reduction of disulfide bonds in proteins that reduces disulfide bonds faster than does dithiothreitol

Author: Singh, Rajeeva ; Whitesides, George M.

N,N'-Dimethyl-N,N'-bis(mercaptoacetyl)hydrazide (DMH) was prepared as a reagent for the reduction of disulfide bonds in proteins.DMH reduces disulfide bonds 7 times faster than does dithiothreitol (DTT) in water at pH 7.DMH reduces mixed disulfides of cysteine proteases (papain and ficin) especially rapidly (30 times faster than DDT).DMH (ε° = -0.300 V) reduces noncyclic disulfides completely, although it is less strongly reducing than DTT (ε° = -0.356 V).

100 Deals associated with AL-05712

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