AG-1295

Graphitic Carbon Nitride (g-C₃N₄) has emerged as one of the desired materials in photocatalysis due to its visible-light activity and its unique layered structure.However, the efficiency of bare g-C₃N₄ as a photocatalyst is limited by the high recombination rate of photogenerated electron-hole pairs.To improve photon utilization and extend the carrier lifetime in the photocatalytic reaction, we composite Fe₂O₃ with g-C₃N₄, greatly enhancing the photocatalytic activity.Fe₂O₃@C₃N₄ achieves C-H functionalization via the Minisci reaction, selectively cleaving the C-N bond in phenylhydrazine to form Ph radicals, followed by nucleophilic addition reactions with protonated quinoline radicals.Notably, the catalyst exhibits high efficiency and excellent yields in large-scale reactions.Moreover, it can be easily recovered by centrifugation and reused at least six times without significant loss of catalytic performance.

The catalytic cycle of mol. iodine is crucial for the activation of acetophenones.In this study, we describe a photooxidative mechanism that regenerates iodine, transforming acetophenones into reactive intermediates, α-iodoacetophenones, for the synthesis of quinoxalines and 2-benzoylquinazolin-4(3H)-ones.Upon exposure to light, the excited state 3CZEPAIPN* serves as an oxidizing agent, capable of oxidizing I^- to I₂.This method was successfully applied to synthesize two EGFR Tyrosine Kinase inhibitors, 6,7-dimethyl-2-phenylquinoxaline and 2-phenylbenzo[g]quinoxaline.